壳聚糖-羟丙甲基纤维素共混膜的生物黏附性  

Bioadhesion Properties of Chitosan and Hydroxypropyl Methyl Cellulose Blended Membrane

作　　者：李若慧[1] 常康威[2] 王思[1] 

机构地区：[1]北京联合大学生物化学工程学院,北京100023 [2]北京航空航天大学材料科学与工程学院,北京100191

出　　处：《化学与粘合》2012年第4期23-27,共5页Chemistry and Adhesion

基　　金：科技部国际合作项目(编号:2010DFB30850-3)

摘　　要：把壳聚糖和羟丙甲基纤维素溶液相混合,通过相转化法成膜工艺制备壳聚糖和羟丙甲基纤维素共混膜,以猪大肠为黏附对象,考察在不同工艺条件下制得的CS/HPMC共混膜对猪大肠的黏附特征,研究结果表明:在越高温度下成膜,生物黏附性能越差;甘油的加入会使共混膜的生物黏附性能下降,当用量增加到0.2g时,生物黏附性能下降变得平缓;制膜液的浓度越高,所成膜的生物黏附性能越好;随着HPMC用量的增加,共混膜的生物黏附性能增强。并阐明CS/HPMC共混膜的生物黏附性能与在不同条件下成膜所得到的膜片材料结构和表面形态之间的关系。扫描电镜照片显示CS/HPMC共混膜的微观形貌呈多孔结构,这种结构对其生物黏附性能有影响。The chitosan （CS） and hydroxypropyl methyl cellulose（HPMC） blended membranes were prepared under different technological con- ditions via L-S phase inversion. The bioadhesion properties of this membrane with pig intestine were investigated in vitro through bioadhesion time and bioadhesion strength. The results showed that the bioadhesion properties declined while forming membranous at a higher temperature; the bioad- hesion time and bioadhesion strength tended to decrease mildly when glycerin added up to 0.2g; the bioadhesion properties of CS/HPMC blended membranes improved with increasing the concentration of membrane liquid and the amount of HPMC. The relationship of bioadhesion properties with the structure and surface morphology of CS/HPMC blended membrane to be formed under different technological conditions was explained. The result of SEM indicated that the surface morphology of blended membrane was porous structure which had effects on the bioadhesion properties.

关 键 词：壳聚糖 羟丙甲基纤维素 共混膜 生物黏附性 

分 类 号：TQ322.97[化学工程—合成树脂塑料工业]