大叶山楝的化学成分研究  

Studies on Chemical Constituents of the Leaves and Twigs of Aphanamixis grandifolia

作　　者：王小英[1,2] 苑春茂[2] 唐贵华[2] 郝小江[2] 赵庆[1] 何红平[2] 

机构地区：[1]云南中医学院中药学院,云南昆明650500 [2]中国科学院昆明植物研究所,云南昆明650201

出　　处：《云南中医学院学报》2012年第4期34-36,43,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金(NO:81060262);云南省中青年学术技术带头人后备人才项目(NO:2010CI047)

摘　　要：目的:对大叶山楝(Aphanamixis grandifolia)的枝叶部分进行化学成分研究。方法:对大叶山楝枝叶的95%乙醇提取物分别经石油醚和乙酸乙酯萃取。乙酸乙酯部分反复利用正相硅胶、反相RP-18、凝胶Sephadex LH-20等色谱方法进行分离纯化,并运用MS和NMR来鉴定化合物的结构。结果:从大叶山楝中分离鉴定了6个化合物,分别为:aromadendrane-4β,10β-diol(I),spathulenol(Ⅱ),eudesm-4(15)-ene-1β,6α-diol(Ⅲ),3α-cimnamoyloxykaur-16-en-19-oic acid(Ⅳ),phillygenin(V),3-methoxybenzoic-4-hydroxy acid(Ⅵ)。结论:6个化合物均为从该属植物中首次分离得到。Objective：To research the chemical constitutes isolated from the leaves and twigs of Aphanamixis grandifolia.Methods：The leaves and twigs of A.grandifolia were extracted with 95% ethanol,which was suspended in water and then extracted successively with petroleum ether and ethyl acetate.The ethyl acetate part was extensively separated over a series of chromatographic methods,including silica gel,RP-18,and Sephadex LH-20.These compounds were elucidated by extensive spectroscopic analysis（MS,NMR,and so on）.Results： Six compounds,[aromadendrane-4β,10β-diol（I）,spathulenol（Ⅱ）,eudesm-4（15）-ene-1β,6α-diol（Ⅲ）,3α-cimnamoyloxykaur-16-en-19-oicacid（Ⅳ）,phillygenin（V）,3-methoxybenzoic-4-hydroxy acid（Ⅵ）.] were isolated and identified.Conclusion：Six compounds were all isolated from genus Aphanamixis for the first time.

关 键 词：楝科 大叶山楝 化学成分 

分 类 号：R282.6[医药卫生—中药学]