GE TRACERLab FX-FN合成器降低^(18)F-FDG合成成本的研究  

THE STUDY OF REDUCING THE SYNTHESIS COST OF ^(18)F-FDG BY GE TRACERLAB FX-FN SYNTHESIZER

作　　者：何玉林[1] 王雪梅[1] 包宝亮[1] 吴君 赵周社 

机构地区：[1]内蒙古医学院附属医院核医学科,内蒙古呼和浩特010050 [2]通用电器(中国)医疗集团

出　　处：《内蒙古医学院学报》2012年第3期217-220,共4页Acta Academiae Medicinae Neimongol

基　　金：国家自然科学基金(81060019);内蒙古医学院青年基金(NY2011QN007)

摘　　要：目的:研究了GE TRACERLab FX-FN合成器降低18F-FDG(氟18-脱氧葡萄糖、[18F]2-fluoro-2-deoxy-D-glucose)正电子药物合成成本方法。方法:本实验分别用华益艾素托福公司生产的国产试剂和ABX公司生产的进口试剂盒各合成了18F-FDG四次。对二种试剂盒合成的18F-FDG进行比活度、PH值、放化产率、放射化学与化学纯度和K2.2.2的含量及试剂成本的对照。结果:国产试剂及进口ABX公司试剂盒四次制备的18F-FDG的放化产率平均值分别为:59.25%和60.25%(t=-2.449,P=0.095>0.05);放射化学纯度平均值分别为:98.75%和99%(t=-1.000,P=0.391>0.05),二者无统计学差异。比活度、pH值、K2.2.2的含量均符合药典要求。国产试剂成本为进口ABX公司试剂盒的成本的1/2。结论:采用华益艾素托福公司试剂合成18F-FDG与进口试剂盒合成的18F-FDG有相同的放化产率、放射化学与化学纯度,而合成成本却比进口试剂盒降低了一半。Objective：To reduce the cost of18F-FDG production on TRACERlab FX FN synthesizer.Methods： We produced 8 batches of18F-FDG.In 4 batches we used FDG chemical kit purchased from ABX（containing precursor,chemicals and Sep-Pak SPE column）,in other 4 batches we used FDG kit purchased from Huayi Isotope Co.（China）.We compared the yield,pH,radio-chemical purity,K2.2.2 residual and production cost of FDG product between ABX and Huayi.Results： 18F-FDG mean yield produced from ABX and Huayi is 60% and 59%,mean radiochemical purity is both 99%,pH value and K2.2.2 redidual both fulfill SFDA demand.However,production cost when using Huayi FDG kit is only half of ABX.Conclusion：the yield and quality of18F-FDG when using Huayi FDG kit as same as ABX,and We reduced half of 18F-FDG production cost.It is good news for China PET center.

关 键 词：国产试剂盒 ABX公司试剂盒 合成方法 

分 类 号：R9[医药卫生—药学] R814.42