异丙酚在不同ABO血型病人的麻醉效果比较  

COMPARISON OF PROPOFOL EFFECT ON PATIENTS WITH DIFFERENT BLOOD GROUPS

作　　者：于建设[1] 石海霞[1] 

机构地区：[1]内蒙古医学院附属医院麻醉科,内蒙古呼和浩特010050

出　　处：《内蒙古医学院学报》2012年第4期321-324,共4页Acta Academiae Medicinae Neimongol

基　　金：内蒙古自治区自然科学基金(2010MS1142)

摘　　要：目的:探讨不同ABO血型病人是否对异丙酚的效果存在差异,以期对临床麻醉应用异丙酚提供个体化依据。方法:择期全麻手术病人80例,年龄40～60岁,体重50～75kg,ASA分级Ⅰ或Ⅱ级,根据血型(n=20)分为A组、B组、AB组、O组。病人入室稳定10min后测定靶控输注异丙酚前T0的MAP、HR和BIS值,之后开始静脉血浆靶控输注异丙酚,初始浓度4μg/mL,目标浓度6μg/mL,分别在靶控浓度4μg/mL(T1)、4.5μg/mL(T2)、5μg/mL(T3)、5.5μg/mL(T4)时测定MAP、HR、BIS值。分别计算每组用异丙酚后各时间点MAP、HR、BIS与麻醉前测定值的差值△。结果:各时间点△MAP、△HR比较,B组最高,(P<0.01),O组次之(P<0.05),而A组和AB组无明显差异。△BIS,只有A组在T3和T4时间点大于其它血型组。结论:不同ABO血型病人异丙酚应用效果存在差异。Objective：To compare the effect of propofol on patients with different blood groups Methods： 80 ASA Ⅰ or Ⅱ patients, age 40 - 60year, weighing 50 - 75 kg, scheduled for selected general anesthesia, were enrolled in this study. According to ABO blood - group system, the patients were divid- ed into 4 groups （ n = 20） ： group A, group B, group coordinated 10 minutes, record the values of MAP, AB, group O. After the patients in operation room HR, BIS before administrating propofol （ T0 ）, then Propofol was administrated by TCI at an effect- site concentration of 4.0μg/mLinitially, the target effect- site concentration was 6μg/mL. Record the values of MAP, HR, BIS at different time points of propofol effect - site concentration respectively, such as 4μg/mL （ T1 ） , 4. 5μg/mL （ T2 ） , 5μg/mL （T3 ）,5.5μg/mL（T4）. Measured the value distance（ △ ）of MAP, HR, BIS at each time point, com- pared with T0as baseline. Results： △ MAP, △ HR were the highest in group B （ P 〈 0. 01 ）, the second in group （ P 〈 0.05 ） , and group A and group B have no significance. Between T3 and T4,△ BIS in group A was higher than the other blood groups. Conclusion：The effect of propofol is different on patients with different blood groups.

关 键 词：ABO血型系统 二异丙酚 镇静 

分 类 号：R614.2[医药卫生—麻醉学]