糖尿病肾病患者血清同型半胱氨酸与氧化应激反应的变化  

The Changing of Diabetic Nephropathy Patients HCA and Oxidative Stress

作　　者：王海英[1] 

机构地区：[1]北京军区总医院检验科,北京100700

出　　处：《中国医药导刊》2012年第8期1408-1409,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨糖尿病肾病患者血清同型半胱氨酸与氧化应激反应的变化。方法:采用回顾性分析的方法,分析我院收治的糖尿病肾病患者50例和健康体检者临床资料。结果:糖尿病肾病组血糖、24h蛋白尿明显高于对照组,糖尿病肾病组SOD、GSH明显低于对照组,而同型半胱氨酸和MDA明显高于对照组,同型半胱氨酸水平>15μmol/L患者SOD、GSH低于≤15μmol/L组,而MDA明显高于≤15μmol/L组,P<0.05,差异均有统计学意义。结论:同型半胱氨酸升高可能是糖尿病肾病的独立的危险因素,对于糖尿病肾病患者同型半胱氨酸水平监测,利于观察患者氧化应激状态情况。Objective：To approach changing of diabetic nephropathy patients HCA and oxidative stress.Methods：To retrospective analyze clinical data of diabetic nephropathy patients 50 cases and health examination Person in our hospital.Results：The BG、24 h albuminuria of diabetic nephropathy group were higher than control group,the SOD、GSH of diabetic nephropathy group were lower than control group,the HCA and MDA were higher than control group,The of SOD、GSH HCA15μmol/L patients were lower ≤15μmol/ L patients,but MDA were higher than ≤15μmol/L patients,P〈0.05,the difference were statistical significance.Conclusion：The HCA were to advance,which was independent risk factor of diabetic nephropathy patients,to be monitoring HCA of diabetic nephropathy patients,which was good for oxidative stress of patients.

关 键 词：糖尿病肾病 同型半胱氨酸 氧化应激 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]