芬太尼透皮贴剂治疗39例中重度癌痛的疗效评价  

Evaluation of the Therapeutic Efficacy of Transdermal Fentanyl Patches in 39 Patients with Moderate to Severe Cancer Pain

作　　者：饶跃峰[1] 张相宜[1] 刘俊青[1] 王飞[2] 程斌[3] 徐敏[4] 张幸国[1] 

机构地区：[1]浙江大学医学院附属第一医院,杭州310003 [2]杭州市第一人民医院,杭州310016 [3]浙江省肿瘤医院,杭州310022 [4]浙江省中医院,杭州310006

出　　处：《中国药学杂志》2012年第17期1415-1417,共3页Chinese Pharmaceutical Journal

基　　金：浙江省医药卫生科学研究基金(2010KYA079)

摘　　要：目的从镇痛效果、生活质量、药物不良反应等方面综合评价芬太尼透皮贴剂对中重度癌痛的治疗效果。方法采用标准病例报告表,结合BPI简明疼痛评估表及NRS数字评分法等方法,对39例首次接受芬太尼透皮贴剂治疗(初始剂量25μg.h-1)的中重度癌痛的患者进行为期5周的用药观察,详细记录病程发展过程并进行汇总分析。结果本实验中39例入组患者治疗有效率97.4%(38/39),平均癌痛缓减幅度达60.3%,患者生活质量改善显著,主要不良反应为便秘、头晕、恶心、嗜睡、皮肤瘙痒等,多数可耐受且治疗后期趋于缓解。结论芬太尼透皮贴剂对中重度癌痛疗效显著,药物不良反应较少,较明显改善患者生活质量,可作为中重度癌痛治疗的推荐药物之一。OBJECTIVE To evaluate the therapeutic efficacy of transdermal fentanyl patches for moderate to severe cancer pain in aspects of pain control, quality of life, ADR, and etc. METHODS Using the standard case report form combined with brief pain inventory（BPI） and numerical rating scale （NRS）, 39 patients with moderate to severe cancer pain who received transdermal fentanyl （ initial dose of 25 μg . h- 1 ） for no less than five weeks were investigated. RESULTS The total effective rate was 97.4% （38/39） and the average pain relief degree was 60. 3%. All the patients gained significant improvement in multiple aspects of the quality of life. The main ADRs included constipation, dizziness, nausea, drowsiness, skin itch and etc, which were endurable, especially in the later therapeutic period. CONCLUSION Transdermal fentanyl patches are the ideal ahernative for patients with moderate to severe cancer pain.

关 键 词：芬太尼透皮贴剂 中重度癌痛 疗效评价 药物不良反应 

分 类 号：R969.4[医药卫生—药理学]