IL-10基因多态性与江苏地区高危人群丙型肝炎病毒感染转归的关联研究  

Association between IL-IO gene polymorphisms and the outcomes of hepatitis C virus infection among high-risk populations in Jiangsu province

作　　者：唐玲燕[1] 王洁[1] 喻荣彬[1] 苏静[1] 许可[2] 彭志行[1] 邓小昭[3] 丁伟良 葛志军 张云[1] 

机构地区：[1]南京医科大学流行病与卫生统计学系,210029 [2]江苏省疾病预防控制中心急性传染病防制科 [3]南京军区军事医学研究所 [4]江苏宜兴人民医院

出　　处：《中华流行病学杂志》2012年第9期898-902,共5页Chinese Journal of Epidemiology

基　　金：国家自然科学基金（81072343）;江苏省自然科学基金（sbk201120309）

摘　　要：目的探讨江苏地区高危人群IL-10基因多态性与丙型肝炎病毒（Hcv）感染转归的关系。方法运用Taqman—MGB技术检测264例HCV自限感染者、371例HCV持续感染者和920例对照者的IL-10—819T／C、-592A／C、-1082A／G位点基因多态性。结果调整性别、年龄和高危人群种类混杂因素后，logistic回归分析显示3个位点的基因多态性分别与HCV感染转归无显著关联（P值均〉0．05）。进-步分层分析显示，-819T／C位点中，TC基因型使中年人、女性和有偿献血人群HCV自限感染的机会增加[调整OR值及其95％C1分别为2．160（1．163．4．011）、1．693（1．066～2．688）和4．084（1．743—9．570）]，在有偿献血人群中使个体进展为持续感染的风险降低（调整OR=0-312，95％CI：0．130～0．747）；CC基因型使血液透析人群HCV自限感染的机会增加（调整OR=2．120，95％CI：1．071～4．197），同时在有偿献血人群中使个体进展为持续感染的风险降低（调整OR=0．156，95％CI：0．043～0．566）。-592A／C位点中，AC基因型使中年人、女性和有偿献血人群HCV自限感染的机会显著增加[调整OR值及其95％C1分别为2．176（1．173，4．037）、1．659（1．055～2．607）和3．704（1．625-8．443）]，在女性中增加了HCV持续感染的风险（调整OR=1．525，95％CI：1．017～2．286），在吸毒人群中使个体进展为持续感染的风险增加（调整OR=1．845和95％CI：1．122—3．034），而在有偿献血人群中使个体进展为持续感染的风险降低（调整OR=0．361，95％CI：0．155。0.841）。CC基因型增加了有偿献血人群HCV自限感染的机会，同时也使个体进展为持续感染的风险降低[调整OR值及其95％C1分别为3．125（1．016—9．605）和0．218（0．063～0．748）]。-1082A／G位点中，突变基因型AG／GG能增加有偿献血人群HCV自限感染的机会（调整OR=3．780，95％CI：1．620—8．Objective To explore the relationship between interleukin （IL）-10 gene polymorphisms and the susceptibility or the outcomes of HCV infection among high-risk populations in Jiangsu province. Methods IL-10 gene SNPs were detected in 1555 subjects including 264 self-limited HCV infections. 371 persistent HCV infections and 920 healthy controls were selected through Taqman-MGB. Results After adjusted for cofounders as sex, age and high-risk population, data from logistic regression analysis showed that the distribution of IL-10 genotypes among the controls, spontaneous clearances and those with persistent infections did not show much differences. Results from further stratified analysis showed that, at the position of-819T/C, when compared with TT genotype, TC genotype had a significantly increasing chance of self-limited HCV infection among middle-aged, females and paid blood doners （adjusted OR values and 95% CI were： 2.160, 1.163-4.011 ; 1.693,1.066-2.688 and 4.084, 1.743-9.570）. It also had a lower risk of progressing to persistent HCV infection among those paid blood doners （the adjusted OR values and 95%CI were： 0.312,0.130-0.747）. CC genotype had a higher chance of self-limited HCV infection among people underwent blood dialysis （the adjusted OR values and 95%CI were： 2.120, 1.071-4.197）. Results also showed a decreased risk of progressing to persistent infection among paid blood doners （the adjusted OR values and 95%CI were： 0.156,0.043-0.566）. At the position of-592A/C, when compared to AA genotype, the AC genotype had a significantly increasing chance of self-limited HCV infection among middle-aged, females and paid blood donets （the adjusted OR values and 95% CI were： 2.176, 1.173-4.037; 1.659, 1.055-2.607; 3.704, 1.625-8.443） but had an increased risk of persistent HCV infection among females （the adjusted OR values and 95%CI were： 1.525, 1.017-2.286）. AC genotype showed an increased opportunity to progress to HCV persistent infection among drug users （the adjuste

关 键 词：丙型肝炎 白细胞介素-10 基因多态性 

分 类 号：R51[医药卫生—内科学]