右美托咪定用于立体定向癫痫病灶毁损术的临床研究  

Application of dexmedetomidine in patients undergoing epileptic focuses stereotactic radio frequency coagulations

作　　者：吕浩[1] 李军[1] 陈宇[1] 刘永勤[1] 赵全军[2] 林鸿[2] 吴朝辉[2] 

机构地区：[1]海军总医院麻醉科,北京市100048 [2]海军总医院全军神经外科中心,北京市100048

出　　处：《临床麻醉学杂志》2012年第8期745-746,共2页Journal of Clinical Anesthesiology

摘　　要：目的观察右美托咪定用于立体定向癫痫病灶毁损术的全麻效果。方法选择立体定向癫痫病灶毁损术患者120例,随机均分为右美托咪定组(D组)和丙泊酚组(C组)。观察痫性放电脑电图监测的纺锤波脑电图和爆发抑制波脑电图的出现情况。结果与C组相比,D组术中深部电极探测出现干扰波形(纺锤波形和爆发抑制波形)的发生比率明显下降(5%vs.75%,P<0.01)。结论机器人辅助无框架立体定向癫痫病灶毁损术使用右美托咪定维持麻醉可以达到理想的麻醉效果,且对脑电图的影响较小。Objective To observe the effect of demnedetomidine in patients undergoing epileptic focuses stereotactic radio frequency coagulations. Methods One hundred and twenty patients were equally randomized into two groups： dexmedetomidine group and propofol group. BP, HR, bispectral index （tSIS） and interferential waves （spindle wave and burst suppression wave） on electroencephalogram （EEG） were recorded. Results Compared with the propofol group, the occurrence frequencies of spindle wave and burst suppression wave in the dexmedetomidine group were decreased （P〈0. 05）. Conclusion Compared with propofol, dexmedetomidine has smaller effect on EEG in patients undergoing epileptic focuses stereotactic radio frequency coagulations.

关 键 词：右美托咪定 癫痫 脑电波 

分 类 号：R614[医药卫生—麻醉学]