血浆APN水平与男性HBP合并CHD患者冠脉病变稳定性的相关性研究  

Correlation between the level of serum adiponectin and the stability of coronary artery atheromatous plaque of coronary artery disease in male patients with hypertension

作　　者：方小丽[1] 何妍[1] 林劲[1] 王圣[1] 林慕如[1] 

机构地区：[1]海南省人民医院心内科,海南海口570311

出　　处：《现代预防医学》2012年第17期4626-4627,4629,共3页Modern Preventive Medicine

摘　　要：目的探讨血浆脂联素(APN)水平对男性高血压病(HBP)合并冠心病(CHD)患者冠脉粥样斑块稳定性的预测价值。方法入选80例因胸闷痛入院行冠脉造影术的男性HBP患者,按临床诊断分组,20例单纯HBP患者,HBP合并ACS患者38例,合并AMI患者20例,合并UAP患者18例;合并SAP患者22例。检测各受试对象的血浆APN水平。结果 HBP合并CHD组的血浆APN水平明显低于单纯HBP组(P﹤0.05);HBP合并ACS组血浆APN水平与HBP合并SAP组比较显著降低(P﹤0.05);HBP合并AMI组血浆APN水平低于HBP合并UAP组,但差异无统计学意义(P﹥0.05)。结论血浆APN水平与男性HBP合并CHD患者冠脉斑块稳定性显著相关,有助于临床预测此类患者冠脉斑块不稳定性。OBJECTIVE To explore the predictive value for the stability of the coronary artery atheromatous plaque in the male patients with HBP combined with CHD.METHODS Analysis was done in 80 male cases with HBP who attended to the cardiovascular department of Hainan province hospital.Those cases were divided into the simple hypertensive group 20 cases,ACS group 38 cases,AMI group 20 cases,UAP group 18 cases and SAP group 22 cases.The level of the serum APN was evaluated.RESULTS The level of serum APN in the HBP combined with CHD group was lower than the simple hypertensive group（P﹤0.05）;the level of serum APN in the ACS subgroup was lower than the SAP subgroup（P﹤0.05）;the level of serum APN in the AMI subgroup was lower than the UAP subgroup,but there was no statistics difference（P﹥0.05）.CONCLUSION The level of serum APN in the male patients with HBP combined with CHD has a correlation to the stability of the coronary artery atheromatous plaque.It takes advantages to predict the stability of the coronary artery atheromatous plaque in the male patients with HBP combined with CHD.

关 键 词：脂联素 男性 高血压病 冠心病 冠脉斑块稳定性 

分 类 号：R541.4[医药卫生—心血管疾病]