高血压合并糖尿病患者血糖对血压及内皮功能的影响  

Effects of blood pressure on endothelial function of plasma glucose control in patients with essential hypertension complicated with type 2 diabetes mellitus

作　　者：魏娜[1] 薛迪中[1] 常万松[1] 庄红丽[1] 

机构地区：[1]中国人民武装警察部队河南总队医院,郑州450052

出　　处：《医药论坛杂志》2012年第8期8-9,共2页Journal of Medical Forum

摘　　要：目的通过对高血压合并2型糖尿病患者血糖水平的控制,探讨不同血糖水平对降压疗效及内皮功能的影响。方法选择住院和门诊高血压合并2型糖尿病患者68例,根据高血压和2型糖尿病治疗指南选择降压和降糖方案,记录患者治疗过程中不同血糖水平时的降压疗效,同时检测治疗开始与结束时的空腹血糖(FPG)、血浆内皮素(ET-1)及尿清蛋白排泄率(Urinary albumin excretion rate,UAER)。结果随着治疗过程中血糖水平的逐渐改善,血压达标人数明显增加。经过4～6周的降糖治疗,血糖接近达标(6.1～6.9mmol/L)和达标(<6.1mmol/L)时,血压达标率分别为82.35%和95.59%,和血糖≥7.0mmol/L(血压达标率51.47%)及≥7.8mmol/L(血压达标率27.94%)水平相比有显著性差异;同时,治疗前后患者FPG、血浆ET-1及UAER均明显下降。结论高血压合并2型糖尿病患者血糖水平与降压疗效关系密切,良好的血糖控制有利于血压的治疗,从而改善内皮功能,更好地预防靶器官损害,防止并发症的发生。Objective To explore the relationship of blood pressure control,endothelial function and plasma glucose level in patients with essential hypertension complicated with type 2 diabetes mellitus.Methods Totally 68 patients with essential hypertension complicated with type 2 diabetes mellitus were treated according to essential hypertension guideline and type 2 diabetes mellitus guideline,and recorded the blood pressure standard at different plasma glucose level,while checked the fasting plasma glucose（FPG）,endothelin-1（ET-1）and Urinary albumin excretion rate（UAER） in plasma at the beginning and end of treatment.Results Through 4-6 weeks therapy the plasma glucose level gradually decline,the compliance rate of blood control increased obviously.At the same time,the level of FPG,ET-1and UAER were significant decreased（P0.05）after treatment.Conclusions Blood pressure control was closed with plasma glucose level in patients with hypertension complicated with type 2 diabetes mellitus,the better plasma glucose control treatment was in favour of blood pressure,so as to improve endothelial function and better prevention target organ damage,prevent the occurrence of complications.

关 键 词：高血压 糖尿病 空腹血糖 内皮素-1 尿清蛋白排泄率 

分 类 号：R544.1[医药卫生—心血管疾病]