小肠与胃间质瘤的临床特点比较  

Clinical analysis on diagnosis and treatment of 26 cases of small bowel stromal tumors

作　　者：何纯刚[1] 黄沁园[2] 吴鸿根[1] 邓洪强[1] 潘云[1] 农淑珍[1] 李林德[1] 

机构地区：[1]广西壮族自治区人民医院普通外科,南宁530021 [2]广西医科大学护理学院,南宁530021

出　　处：《中国临床新医学》2012年第8期722-724,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西卫生厅科研课题(编号:Z2011475)

摘　　要：目的探讨小肠间质瘤的临床特征及诊治。方法收集2004～2010年诊治的资料齐全的小肠间质瘤26例,并对其临床资料进行回顾性分析。结果最主要的临床表现为腹部包块、腹部胀痛、解黑便。肿瘤源于十二指肠3例,空肠18例,回肠5例,浸润邻近器官2例,伴远处转移4例。免疫组化:CD117、CD34、Desmin、Actin、S-100、NSE阳性率分别为96.2%、76.9%、3.8%、23.1%、0.0%、26.9%。22例行根治术,均获得随访,10例死亡,平均生存时间50个月。小肠间质瘤26例与同期诊治的胃间质瘤46例各免疫组化指标、临床病理因素、预后等差异均无统计学意义(P>0.05)。结论小肠间质瘤与胃间质瘤有相似的临床病理特点及预后;术前合理选择辅助检查方法很重要,手术仍是目前主要的治疗方法,术后应长期随访。Objective To explore the clinical characteristics, diagnosis and treatment methods of small bow- el stromal tumors. Methods Twenty-six patients with small bowel stromal tumors was collected from 2004 to 2010, and the clinicopathologie data and survival data was reviewed retrospectively. Results Of 26 patients with small bowel stromal tumors, there were 15 males and 11 females, the median age was 51 years old. The most common clinical manifestation was finding of tumor in abdomen, abdominal pain and melena. Tumor originated from duodenum, jeju- num, ileum were 3, 18 and 5 patients, respectively. Two patients got infiltration of adjacent organs, while 4 patients had distant metastasis~ The positive rates of immunohistochemieal staining of CD117, CD34, Desmin, Actin, S-100, NSE were 96. 2% ,76. 9% ,3.8% ,23.1% ,0. 0% ,26. 9%, respectively. Twenty-two patients received radical resec- tion and were followed-up, ended up with 10 deaths, and the mean survival time was 50 months. There were no sig- nificant differences in immunohistochemieal staining, clinieopathologic factors and prognosis between small bowel and gastric stromal tumors （ P 〉 0. 05 ）. Conclusion Small bowel stromal tumors have similar clinical characteristics and prognosis to gastric stromal tumors. It is important to choose rational auxiliary examinations preoperatively. Radical resection may be the mayor treatment, and long-time foUowing-up should be proposed after operation.

关 键 词：胃肠道肿瘤 临床特征 诊断 治疗 

分 类 号：R656.7[医药卫生—外科学]