血T淋巴细胞亚群水平与乙型肝炎病毒再激活关系的研究  

Study on the relationship between blood T-lymphocyte subsets level and hepatitis B virus reactivation

作　　者：庄见齐[1] 王光丽[1] 郑晓辉[2] 黄可青[1] 郑晓丹[3] 

机构地区：[1]汕头大学医学院第一附属医院感染科,广东省汕头515041 [2]汕头大学医学院第一附属医院药剂科,广东省汕头515041 [3]汕头市中心医院感染科

出　　处：《中国基层医药》2012年第19期2897-2898,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省科技计划项目（20108031600283）

摘　　要：目的探讨乙型肝炎（乙肝）病毒再激活与血T淋巴细胞亚群变化的关系。方法使用流式细胞仪（流式细胞EPICSXL）检测40例慢性乙肝病毒携带者与35例乙肝病毒再激活患者T淋巴细胞亚群（CD3、CD4、CD8、CD4／CD8）水平。结果乙肝病毒再激活患者CD3、CD4及CD4／CD8均显著低于慢性乙肝病毒携带者[（71．31±5．20）％与（68．57±6．10）％、（37．82±4．90）％与（32．12±5．93）％、（1．37±0．28）与（1．18±0．43），均P〈0．05]。结论CD3、CD4低水平及CD4／CD8比例的明显下降可能是引起乙肝病毒再激活的重要原因之一。Objective To investigate the relationship between hepatitis B virus reactivation and the level of blood T-lymphocyte subsets. Methods T lymphocyte subsets （ CD3, CD4, CDs ）, CD4/CDs level of 40 patients with chronic carriers of hepatitis B virus and 35 patients with hepatitis B virus re-activation were detected by Flow cytome- try（Epics XL）. Results The hepatitis B virus reactivation in patients with CD3 , CD4 and CD4/CDs levels were significantly lower than the chronic hepatitis B virus carriers,The difference between the two groups patients was significant[ （71.31 ±5.20）% vs （68.57±6.10）% ,（37.82 ±4.90）% vs （32. 12 ±5.93）%,（1.37±0.28） vs （1.18± 0.43） ,all P 〈0.05 ]. Conclusion The levels of CD3 ,CD4 and CD4/CD8 ratio were significantly declined,it may be the one important reason of hepatitis B virus reactivation.

关 键 词：肝炎 乙型 慢性 T淋巴细胞亚群 再激活 

分 类 号：R512.62[医药卫生—内科学]