川丹灵胶囊的质量标准研究  

Study on Quality Standard of Chuandanling Capsules

作　　者：苏华[1] 侯中华[1] 陈翠[1] 王曙东[1] 

机构地区：[1]南京军区南京总医院制剂科,南京210002

出　　处：《中国药房》2012年第35期3348-3349,共2页China Pharmacy

摘　　要：目的:建立川丹灵胶囊的质量标准。方法:采用薄层色谱(TLC)法对方中丹参进行定性鉴别;采用高效液相色谱法测定制剂中腺苷的含量。结果:TLC斑点清晰、分离度好,阴性对照无干扰;腺苷检测浓度在20.42～102.10μg·mL-1范围内与峰面积积分值呈良好的线性关系(r=0.9999),平均加样回收率为101.8%,RSD=2.05%(n=9)。结论:所建标准可用于川丹灵胶囊的质量控制。OBJECTIVE： To establish the quality standard of Chuandanling capsules. METHODS： Qualitative identification of Salvia miltiorrhiza was conducted by TLC. The content of adenosine was determined by HPLC. RESULTS： The developed TLC spots were clear, well-separated and free from interference of negative sample. The linear range of adenosine was 20.42-102.10 μg.mL^-1（r=0.999 9） with an average recovery of 101.8% （RSD=2.05% ,n=9）. CONCLUSION： The established standard can be used for quality control of Chuandanling capsules.

关 键 词：川丹灵胶囊 薄层色谱法 腺苷 高效液相色谱法 

分 类 号：R284.2[医药卫生—中药学] R283.621[医药卫生—中医学]