硅气凝胶负载洛伐他丁的研究  

Study of Silica Aerogels' Loaded Lovastatin

作　　者：陈蔚萍[1] 张小勇[1] 杨浩[1] 乔聪震[1] 

机构地区：[1]河南大学化学化工学院精细化学与工程研究所,河南开封475004

出　　处：《河南大学学报（自然科学版）》2012年第4期367-370,共4页Journal of Henan University:Natural Science

基　　金：河南省教育厅自然科学基金项目(2007530002)

摘　　要：利用超临界技术,通过吸附、结晶作用制备扩孔二氧化硅气凝胶负载洛伐他丁.采用FTIR、TG、N2吸附-脱附和HPLC等分析方法对负载过洛伐他丁的硅气凝胶样品进行了表征.结果表明:用硅气凝胶负载过药物的样品既有硅气凝胶的骨架结构又有药物的官能团说明硅气凝胶负载上了部分洛伐他丁药物;BET表征结果显示负载过药物的样品的吸附量有了明显的降低,说明有一部分药物结晶在硅气凝胶的孔道里面;热重数据显示硅气凝胶对洛伐他丁有一定的负载率(9.0%左右);用HPLC测定样品的释放性显示经过硅气凝胶负载过的洛伐他丁的样品有一定的缓释效果,显示硅气凝胶的负载量随着硅气凝胶孔径的增加而升高.Silica aerogels were carried with lovastatin by adsorption and crystallization in supercritical CO2. Factors and difference pore size influence the loading of silica aerogels. FTIR,TG and N2 adsorption/desorption were used to analyze and characterize the samples. Results show that the loaded samples both skeleton structure of silica aerogels and skeleton structure of lovastatin, the absolute quantity of loaded samples were smaller than absolute quantity of silica demonstrate that a little of lovastatin crystallize in silicas＇ pore by BET, the loading rate of silica aerogels up to 9.0 % by TG, the loading of silica increased with the improvment of the pore size of silica.

关 键 词：气凝胶 洛伐他丁 吸附 超临界二氧化碳 

分 类 号：TQ127.2[化学工程—无机化工]