中心组合设计-响应面分析法优选莽吉柿果皮中α-mangostin的超声提取工艺  

Optimize Technique of Extracting α-mangostin from Pericarp of Garcinia mangostana by Supersonic Wave Using Central Composite Design-Response Surface Methodology

作　　者：赵岩[1,2] 唐强[1] 金达明[1] 王鑫[1] 张连学[1,2] 

机构地区：[1]吉林农业大学中药材学院,吉林长春130118 [2]吉林省人参工程技术创新中心,吉林长春130118

出　　处：《中药材》2012年第6期973-977,共5页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金(31000154);国家科技支撑计划项目(2011BAI03B01);吉林省教育厅"十二五"科学技术研究资助项目(2011-36);吉林省科技发展计划项目(20111615)

摘　　要：目的:优化莽吉柿果皮中α-mangostin的提取工艺。方法:采用中心组合设计方法,研究乙醇浓度、超声时间、液固比及其交互作用对α-mangostin提取率的影响。应用SAS软件和响应面分析相结合的方法,模拟得到回归方程的预测模型和可信度,并通过岭脊分析得到最佳的提取条件。结果:最佳提取条件为:乙醇浓度67.8%、超声提取时间85.9 min、液固比24.2 mL/g。该条件下提取率为5.53%。结论:本研究为工业化提取α-mangostin提供了有效方法。Objective： To optimize the extraction technique for α-mangostin from pericarp of C, arcinia Mangostana. Methods： The effects of ethanol concentration, ultrasonic extraction time, the liquid to solid ratio and their interaction on extraction rate were studied by central composite design. The predictive model and reliability were developed by SAS software and response surface analysis. The optimal ultrasonic extraction conditions were achieved. Resuhs： The optimal ultrasonic extraction conditions were as follows： ethanol concentration 67. 8%, ultrasonic extraction time 85.9 min, the liquid to solid ratio 24. 2 mL/g. Under the optimum conditions, the extraction yield of α-mangostin was 5.53%. Conclusion： This study provides an effective method for the industrial extraction of α-mangostin.

关 键 词：莽吉柿 α—mangostin 提取工艺 中心组合设计 响应面分析 

分 类 号：R286.1[医药卫生—中药学]