甲酰四氢叶酸钙对5-Fu抗肿瘤活性的增效作用  

ENHANCING 5-FU ANTITUMOR EFFECT BY LEUCOVORIN

作　　者：金天明[1] 刘旭波[1] 赵体平[1] 

机构地区：[1]上海医科大学肿瘤医院

出　　处：《肿瘤》1990年第4期164-166,共3页Tumor

摘　　要：甲酰四氢叶酸钙(CF)一直是作为抗癌药MTX的解毒救援剂,本身并无抗癌活性。但文献报道,细胞内高浓度的CF,可增加5-Fu抑制脱氧胸苷酸合成酶活性。近年临床研究提示,CF能增高5-Fu对胃肠道恶性肿瘤的疗效;但也有部分临床实验结果表明并无增效作用。因此,CF对5-Fu抗癌活性影响究竟如何目前尚无定论。我们采用体外细胞实验方法,以人胃癌细胞SGC-7901为材料,The enhancement of the 5-Fu antitumor effect by leucovorin is still controverdial inclinical reports. This study showed that leucovorin was used in combination with 5-Fuagainst human gastric carcinoma cells (SGC-7901) in vitro, even when the concentra-tion of leucovorin was between 0.01--100μg/ml, it could already potentiate the anti-tumor effect of 5-Fu by 30%.The leucovorin can be considered as a biochemicalmodulator for 5-Fu. and a lower dosage deserves trial for clinical use. Flow cytometrystudy confirmed the above findings.

关 键 词：四氢叶酸钙 5-FU 抗肿瘤活性 

分 类 号：R979.1[医药卫生—药品]