凯西莱联合天晴甘美治疗化疗后肝损害的临床疗效  

Effect of magnesium isoglycyrrhizinate and tioprpnin in the treatment of the hepatotoxicity caused by anti-tumor agents in cancer patients

作　　者：张华[1] 金建华[1] 陆文斌[1] 邓建忠[1] 王芳[1] 李献文[1] 赵刚[1] 

机构地区：[1]江苏大学附属武进医院肿瘤内科,213002

出　　处：《中国现代药物应用》2012年第18期5-6,共2页Chinese Journal of Modern Drug Application

摘　　要：目的观察凯西莱联合天晴甘美对于恶性肿瘤患者接受化疗时并发药物性肝损害的治疗作用。方法将化疗后出现药物性肝损害60例患者分为2组,治疗组(30例)予以凯西莱联合天晴甘美;对照组(30例)予以凯西莱,观察比较两组患者治疗肝损害的疗效,1次/d,连用2周。结果 2周后,两组丙氨酸氨基转移酶、天门冬酸氨基转移酶及总胆红素较治疗前均明显下降(P<0.01),两组之间无显著性差异(P>0.05),但显效率治疗组(76.7%)明显高于对照组(50%)(P=0.03)。结论凯西莱联合天晴甘美对恶性肿瘤患者化疗药物性肝损害有较好的治疗作用。Objective To explore an effective therapy for medicamentous liver lesion induced by chem- otherapy in cancer patients. Methods A total of 60 patients with malignant tumor complicated with medica- mcntous liver lesion induced by chcmotherapywcre randomly assigned to receive magnesium isoglycyrrhizinate and fioprpnin（ treatment group） or tioprpnin for injection（ control group） iv gtt qd for 2 consecutive weeks. Re- stilts After the treatment for 2 weeks, levels of alanine aminotransferase （ ALT）, aspartate aminotransferase （AST） and total bilirubin （TB） decreased in both groups （P 〈 0. 01 ） ,but there was no significant difference between two groups（P 〉0. 05）. The rate of marked improvement（76. 7% in treatment group and 50% in con- trol group） was a significant difference （ P = 0. 03 ）. Conclusion Magnesium isoglycyrrhizinate and tioprpnin is effective in the treatment of the hepatotoxicity caused by chemotherapy in patients with malignant tumors.

关 键 词：凯西莱 天晴甘美 化疗药物 药物性肝损害 

分 类 号：R595.3[医药卫生—内科学]