慢性阻塞性肺疾病急性发作中病毒感染的特点与临床分析  

Clinical analysis of virus infection in acute exacerbation of chronic obstructive pulmonary disease

作　　者：葛艳 

机构地区：[1]驻马店市第一人民医院,463000

出　　处：《中国现代药物应用》2012年第18期16-17,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨病毒感染在慢性阻塞性肺疾病急性发作(AECOPD)中的特点及其对AECOPD的影响。方法将176例AECOPD患者、133例COPD稳定期患者、80例健康者分别纳入Ⅰ组、Ⅱ组和健康组,对3组人群进行病毒感染率及病毒特异性抗体检测,并进行组间比较。结果Ⅰ、Ⅱ组患者的病毒感染率显著高于健康组(P<0.05),Ⅰ组的IgM阳性率显著高于Ⅱ组和健康组(P<0.05),Ⅰ、Ⅱ组的IgG阳性率显著高于健康组(P<0.05)。Ⅰ组患者IgM中ADV、RSV阳性率显著高于Ⅱ组和健康组(P<0.05),Ⅰ、Ⅱ两组患者IgG中ADV、RSV、CMV、HSV均显著高于健康组(P<0.05)。结论病毒感染与AECOPD关系密切,且病毒潜在的反复感染是CDPD病情的发展恶化的重要因素。Objective To investigate the clinical effect of virus infection in acute exacerbation of chro- nic obstructive pulmonary disease （AECOPD） and the feature of virus infection. Methods 176 patients with AECOPD, 133 patients in stable stage, 80 cases of healthy people were included into group I , group II , and healthy group, infection rate and virus-specific antibodies of three groups were detected and compared. Results Infection rates of group I and II were higher than healthy group （ P 〈 0.05 ）, positive rate of IgM in group I was higher than that in group II （ P 〈 0.05 ） , positive rates of IgG in group I and I1 were higher than that in healthy group （ P 〈 0.05 ）. ADV, RSV, CMV, HSV of IgG in group I and I1 were higher than healthy group sig- nificantly（ P 〈 0.05 ）. Conclusion Virus infection is closely related to AECOPD, and recurrent infections caused by virus are the improtant factors of disease progression in COPD.

关 键 词：慢性阻塞性肺疾病急性发作 病毒感染 病毒特异性抗体 

分 类 号：R563.9[医药卫生—呼吸系统]