芳香开窍类中药对血脑屏障结构及功能影响的研究进展  

Research Development on the Influence of Traditional Chinese Aromatic Medicine on the Structure and Function of Blood- brain Barrier

作　　者：迟雪洁[1,2] 黄幼异[3] 孙蓉[1] 

机构地区：[1]山东省中医药研究院,山东济南250014 [2]天津中医药大学,天津300193 [3]山东中医药大学,山东济南250355

出　　处：《中国药物警戒》2012年第9期532-534,共3页Chinese Journal of Pharmacovigilance

基　　金：科技部重大新药创制专项:中药复方药理学研究及药效学评价关键技术(2009ZX09502-015);山东省自然基金项目(Y2003C02);山东省博士后创新项目(200801002);济南市重大科技招标项目(064036);山东省重大新药创制综合性大平台中药单元平台中药药理与毒理子平台建设(2009ZX09301-013)

摘　　要：目的综述近年来芳香开窍类中药对血脑屏障(BBB)结构及功能的影响,为从中药"芳香开窍"的传统功效中挖掘、筛选、评价和研发创新药物提供文献依据和研究思路。方法对近10年来芳香开窍类中药对血脑屏障结构及功能影响的国内外相关文献进行整理、归纳、分析。结果药理学研究证实芳香开窍类中药主要通过自由透过血脑屏障发挥药效、降低BBB的通透性以保护脑组织以及促进血脑屏障开放三个方面来改变血脑屏障的通透性,另外其作用机制可能与抑制BBB上P-gp的表达和功能有关。结论从P-gp方面加强对芳香开窍类中药作用机制的研究和探索芳香开窍类中药的功效物质基础将是今后研究的重点。Objective The influence of Traditional Chinese Aromatic Medicine on the structure and function of blood-brain barrier, to provide accordance and research ideas for digging, screening, evaluating, developing original new drug from the traditional effect ＂aromatic and resuscitation＂. Methods The related references in recent 10 years both at home and abroad about Traditional Chinese Aromatic Medicine were collated, analyzed and summarized. Results Modem pharmacological studies indicate that the permeability of BBB could be changed by Traditional Chinese Aromatic Medicine in three ways, first it can develop potency by permeating the BBB reinlessly, second it can protect the brain tissue by reducing the permeability of BBB, third it can promote the opening of BBB, while its mechanism of action may be concerned with restraining the expression and function of P-glycoprotein. Conclusion We can lucubrate mechanism of action in traditional Chinese aromatic medicine from P-gp, as well as explore the effective material basis. This will becomg investigate focal point.

关 键 词：芳香开窍类中药 血脑屏障 结构 功能 

分 类 号：R285.5[医药卫生—中药学]