舒肝解郁胶囊治疗抑郁障碍患者性别差异研究  

作　　者：薄宇清 陈喜恩[1] 刘霞[1] 

机构地区：[1]河南新乡市中心医院综合一科,453000

出　　处：《中国社区医师（医学专业）》2012年第24期153-154,共2页

摘　　要：目的:观察舒肝解郁胶囊治疗抑郁障碍的疗效,不良反应在性别上的差异。方法:将21例抑郁障碍患者按性别分组,男性组10例,女性组11例,入组使用舒肝解郁胶囊0.72g,2次/日,疗程6周,以汉密尔顿抑郁量表(HAMD)在治疗前及治疗后2,4,6周各评定1次疗效,观察记录过程中不良反应的发生情况并以不良反应量表(TESS)评定药物不良反应。结果:男性组显效率(90%)明显高于女性组(72.7%,P<0.05);两组治疗前及治疗2周HAMD评分比较无明显差异(P>0.05),两组治疗4周和6周时与治疗前HAMD评分比较均有明显差异(P<0.05),男性组治疗4周和6周时HAMD评分低于女性组(P<0.05),治疗1周后,女性组不良反应发生率明显高于男性组(P<0.05)。结论:舒肝解郁胶囊治疗抑郁障碍的疗效肯定,但存在明显的性别差异,不良反应较少,且不良反应发生率也存在明显的性别差异,提示对女性患者在抗抑郁治疗过程中,应根据其性格特点多辅以心理康复治疗,并加强对症处理。Objective：To observe sex differences in efficacy and side reaction of shugan jieyu jiaonang for treatment of depressive disorder.Methods：Twenty-one patients with depressive disorder were divided acording to gender：male group including 10patients and female group including 11patients.All patients were administered with 0.72（twice a day） shugan jieyu jiaonang for 6weeks.Efficacy was evaluated before treatment and 2,4and 6weeks after treatment by Hamilton ’sdepression scale（HAMD）,occurrence of side reactions were observed and recorded during course of treatment and drug obverse reaction was evaluated by treatment emergent symptom scale（TESS）.Results：Excellence rate in male group（90%） was obviously higher than that in female group（72.7%）（P 〈 0.05）.There was no significant difference in HAMD scores before treatment and 2 weeks after treatment in tow groups（P 〉 0.05）.There were obvious differences in HAMD scores between 4 weeks and 6 weeks of treatment and before treatment（P 〈 0.05）.HAMD sores in male group were lower than those in female group 4 weeks and 6 weeks of treatment（P 〈 0.05）.Occurrence rate in female group was obviously higher than that in male group after 1 week of treatment（P 〈 0.05）.Conclusion：It is affirmative efficacy of shugan jieyu jiaonang for treatment of depressive disorder.however,there are predominant sex differences,few side reactions and there is sex difference in side reaction,which indicates combination of psychological treatment and symptomatic treatment is performed for treatment of female depressive disorder according to their character.

关 键 词：舒肝解郁胶囊 抑郁障碍 性别差异 

分 类 号：R472.92[医药卫生—护理学]