构建大肠癌转移动物模型的研究进展  

Research Progress of Establishing Metastatic Colorectal Carcinoma Animal Models

作　　者：臧怡雯[1] 陈宗祐[1] 

机构地区：[1]复旦大学附属华山医院普外科,上海200040

出　　处：《医学综述》2012年第16期2587-2590,共4页Medical Recapitulate

摘　　要：建立合适的动物模型是研究结直肠癌发病及转移机制的重要方式之一。理想的肿瘤转移模型应当具备:肿瘤成瘤潜伏期短、转移率高、病死率低或死亡等不良事件发生较晚,并且能共模拟结直肠癌临床生物学等特点。直接将结直肠癌细胞注射入循环系统的实验性转移模型是快速建立肝、肺转移的方法。而原位或皮下移植瘤的自发性转移模型则能反映肿瘤突破基底层侵袭扩散的转移早期过程。如何选择应由研究的目的来决定。A suitable animal model may help reveal the underlying pathogenesis of metastatic colorectal carcinoma.An ideal metastatic model should be featured with：short latent period,high metastatic rate,low death rate,and good biosimulation of tumors in vivo.Spontaneous metastatic models may recreate the important early phase of malignant tumor metastasis：invasion and shedding cells from a primary tumor into circulation;while experimental models can rapidly establish liver or lung metastasis through directly injecting cancer cells into circulation or target organ.Considering the efficiency,the best way of modeling depends on the purpose of scientific researches.

关 键 词：结直肠癌 转移 动物模型 

分 类 号：R656[医药卫生—外科学]