长托宁治疗重症有机磷农药中毒的心脏保护作用  

Therapeutic Protection of PHC in the Treatment of Severe Organophosphorus Pesticide Poisoning

作　　者：卢红元 钱梦勇[2] 

机构地区：[1]陕西省博爱医院急诊科,西安710065 [2]西安交通大学第一附属医院医务科,西安710061

出　　处：《医学综述》2012年第16期2707-2708,共2页Medical Recapitulate

摘　　要：目的探讨长托宁救治重症有机磷农药中毒的应用效果与机制。方法选择成年健康SPF级Wistar大鼠90只,随机分为正常对照组、阿托品组与长托宁组,各30只。阿托品组与长托宁组首先给予相应剂量的有机磷农药灌胃,对照组给予蒸馏水灌胃,阿托品组与长托宁组染毒后30 min开始分别给予阿托品与长托宁治疗。比较各组血清心肌酶各指标与血清胆碱酯酶(CHE)的变化并进行病理学观察。结果与治疗前比较,治疗后阿托品组与长托宁组血清肌酸激酶同工酶、谷草转氨酶、肌酸激酶、乳酸脱氢酶水平均明显下降,长托宁组下降幅度更大(P<0.05),且两组CHE活力均明显上升,长托宁组上升幅度高于阿托品组(P<0.05);组织病理学检测显示治疗后阿托品组与长托宁组肺损伤明显减轻。结论长托宁救治重症有机磷农药中毒有较好的治疗保护作用,值得推广。Objective To investigate the effect and mechanism of penehyclidine hydrochloride（PHC）injection in the treatment of severe organophosphorus pesticide poisoning.Methods 90 healthy adultSPF Wistar rats were randomly divided into the normal control group.atropine group and PHC group.The atropine group and the PHC group were given the appropriate dose of organophosphate pesticides by gavage,and the control group was given distilled water;atropine group and the PHC group were given atropine and PHC 30 min after poisoning.The changes of serum cardiac enzymes indexes and the serum cholinesterase（CHE）were compared and histopathological observation was done.Results After treatment,the serum isoenzyme of creatine kinase,aspartate aminotransferase,creatine kinase,lactate dehydrogenase decreased significantly in the atropine group and PHC group,more sharply in PHC group（P0.05）.And the serum CHE activity were significantly increased after treatment while the rise in PHC group were more than atropine group（P0.05）.Lung injury of the two groups after treatment were significantly reduced through histopathological test.Conclusion PHC has a better therapeutic and protective effect in the treatment of severe organophosphorus pesticide poisoning,and should be promoted.

关 键 词：长托宁 有机磷农药中毒 心肌酶 

分 类 号：R595.4[医药卫生—内科学]