子宫内膜异位症发病机制研究进展  

The Advance of the Endometriosis in the Pathogenesis

作　　者：周礼兰[1] 林婉君[1] 

机构地区：[1]天津市中心妇产科医院妇科,300100

出　　处：《国际妇产科学杂志》2012年第4期395-398,共4页Journal of International Obstetrics and Gynecology

摘　　要：子宫内膜异位症是育龄妇女的常见病、多发病。目前公认的发病机制是经血逆流、子宫内膜种植学说。其中基质金属蛋白酶(MMP)及其抑制剂(TIMP)、抑制蛋白家族成员——Survivin、血管内皮生长因子(VEGF)等蛋白和因子在子宫内膜异位症的发生中起重要作用,通过抑制或增加这些蛋白或因子的合成可为治疗子宫内膜异位症提供新的突破。Endometriosis is the common and frequent disease in the women of child-bearing age.Currently,the generally received pathogenesis of endometriosis is the theory of retrograde menstruation or implantation.Reflux of endometrium spill into the abdominal cavity,which must by adhere,invade and angiogenesis,developing endometriosis.In addition,this progress must be completed under the factors as some protease,cytokines and so on.Several proteins and cytokines,such as matrix metalloproteinase（MMP）,tissue inhibitor of metalloproteinase（TIMP）,Survivin（a member of the inhibitors of apoptosis protein）andvascular endothelial growth factor（VEGF）,play an important role in the pathogenesis of endometriosis.By inhibiting or increasing the synthesis of these proteins or cytokines,we may get a new breakthrough in the cure of endometriosis.

关 键 词：子宫内膜异位症 基质金属蛋白酶类 金属蛋白酶1组织抑制剂 基因 抑制 血管内皮生长因子类 

分 类 号：R711.71[医药卫生—妇产科学]