国产甲型肝炎疫苗免疫学效果观察评价  

Study on Evaluation the Immunology Effectiveness of Domestic Prodeced Hepatitis A Vaccine

作　　者：安婧[1] 张晓曙[1] 刘建峰[1] 傅鸿 高丽[1] 李慧[1] 

机构地区：[1]甘肃省疾病预防控制中心,兰州730000

出　　处：《中国疫苗和免疫》2012年第4期307-310,315,共5页Chinese Journal of Vaccines and Immunization

基　　金：国家科学技术重大专项传染病及病媒生物控制适宜技术研究项目不同甲型肝炎疫苗免疫效果及应急适宜技术研究课题(编号:2008BAI56800)

摘　　要：目的通过观察接种后不同时间甲型肝炎(甲肝)疫苗的免疫学效果,为甲肝爆发或流行期间的免疫策略提供参考。方法选择6～10岁甲肝易感儿童作为研究对象,利用随机、盲法原则将研究对象分为4组,分别接种国产甲肝减毒活疫苗(Domestic Hepatitis A Attenuated Live Vaccine,dHepA-L)、国产灭活甲肝疫苗(Domestic Hepatitis A Inactivated Vaccine,dHepA-I)、进口(Import)HepA-I(iHepA-I)、重组乙型肝炎疫苗(酿酒酵母)(Hepatitis B Vaccine Made by Recombinant Deoxyribonucleic Acid Technigues inSaccharomyces CerevisiaeYeast,HepB-SCY)。于接种后1、2、4周检测抗甲肝病毒抗体(Antibody to Hepatitis A Virus,Anti-HAV)。结果接种后第1周,nHepA-L、nHepA-I、iHepA-I的Anti-HAV阳转率分别为7.80%、23.81%、15.79%。几何平均浓度(Geometric Mean Concentration,GMC)分别为5.28、6.87、6.97毫国际单位/毫升(mIU/ml)。接种后第2周,nHepA-L、nHepA-I、iHepA-I的Anti-HAV阳转率分别为85.00%、94.59%和83.33%,GMC分别为29.78、47.42、31.08mIU/ml。接种后第4周,nHepA-L、nHepA-I、iHepA-I的Anti-HAV阳转率分别为97.50%、100.00%、94.59%,GMC分别为32.08、45.81、55.87mIU/ml。结论三种HepA均有良好的免疫学效果。甲肝爆发或流行时,使用nHepA-I可控制疫情。Objective To observe immunogenicity efficacy of hepatitis A vaccines which is vaccinated at different times, and to provide a scientific evidence for formulating immunization strategies. Methods Choose children of 6-10 years old who are susceptible to hepatitis A virus, then randomly divided them into two experimental groups and two control groups. We offered domestic produced hepatitis A attenuated live vaccine （dHepA-L）, domestic hepatitis A inactivated vaccine, （dHepA-I）,import hepatitis A inactivated vaccine （iHepA-I）, hepatitis B vaccine made by recombinant deoxyribonucleic acid technigues in saccharomyces cerevisiae yeast （HepB-SCY）to four groups respectively. The overall positive rates of Antibody to Hepatitis A Virus （Anti-HAV） of the research objects were detected after one, two and four weeks. Blind method was used in the process of experimental research. Result The overall positive rates of Anti-HAV of three groups were 7.80%,23.81% and 15.79% respectively, which were vaccinated with dHepA-L, dHepA-I and iHepA-I after one week, while the Anti-HAV IgG geometric mean concentration （GMC）were 5.28 mlIU/ml,6.87 mlIU/ml and 6.97 mlIU/ml; The rates of dHepA-L, dHepA-I and iHepA-I were 85.00%,94.59% and 83.33% respectively, while the GMC of Anti-HAV IgG of three groups were 29.78 mlIU/ml,47.42 mlIU/ml and 31.08 mlIU/ml after two weeks; The rates of dHepA-L,dHepA-I and iHepA-I were 97.50%,100.00% and 94.59% respectively,while the GMC of Anti-HAV IgG of three groups were 32.08 mllU/ ml,45.81 mllU/ml and 55.87 mllU/ml respectively after four weeks. Conclusion Three kinds of hepatitis A vaccine have good immunogenicity efficacy. The domestic live attenuated hepatitis Avaccines were more efficiently when hepatitis A breake out or prevalent.

关 键 词：甲型肝炎疫苗 免疫学效果 评价 

分 类 号：R512.61[医药卫生—内科学] R186[医药卫生—临床医学]