罗哌卡因与左旋布比卡因用于臂丛阻滞麻醉与镇痛效果的Meta分析  

Efficacy of ropivacaine and levobupivacaine in brachial plexus block： a Meta-analysis

作　　者：林志强[1] 李义贤[1] 

机构地区：[1]广东省汕头大学医学院附属肿瘤医院麻醉科,515031

出　　处：《实用疼痛学杂志》2012年第3期220-223,共4页Pain Clinic Journal

摘　　要：目的对比评价罗哌卡因与左旋布比卡因的麻醉与镇痛效果。方法检索PubMed、中国学术期刊全文等数据库中罗哌卡因与左旋布比卡因在臂丛阻滞麻醉与镇痛中的对比研究，利用Meta分析专用软件RevMan5．0进行系统评价，分析罗哌卡因与左旋布比卡因在感觉与运动阻滞起效、恢复时间的差异。结果最终有8篇研究纳入Meta分析，其中罗哌卡因组219例，左旋布比卡因组221例。罗哌卡因与布比卡因在感觉、运动阻滞起效时间差异无统计学意义（z=0．55，P=0．58；Z=1．76，P=0．08），但左旋布比卡因的感觉和运动阻滞持续时间均长于罗哌卡因（P〈0．05）。结论罗哌卡因与左旋布比卡因用于臂丛阻滞麻醉与镇痛效果相同，但又各具优势，可按实际臂丛阻滞麻醉情况进行有效取舍。Objective To investigate the efficacy of ropivacaine and levobupivacaine in the bra- chial plexus block. Methods The randomized controlled trials that compared ropivacaine and levobupivacaine for brachial plexus block were identified in databases of PubMed and CNKI. Then, the onset and duration time of sensory and motor block were evaluated using RevMan 5.0 software. Results Eight studies involving 219 cases received ropivacaine and 221 received levobupivacaine were included in the recta-analysis. There were no statistical significance between the ropivacaine and bupivacaine in onset time of sensory and motor block （Z ： 0.55, P = 0.58 ; Z = 1.76, P = 0.08）. The durations of sensory and motor block of levobupivacaine was significantly longer than that of ropivacaine （P^0.05）. Conclusion The effect of ropivacaine and levobupivacaine in brachial plexus block is similar, and the clinician should choose them based on their character for brachial plexus block.

关 键 词：酰胺类 布比卡因 臂丛 神经传导阻滞 META分析 

分 类 号：R971.2[医药卫生—药品]