正常猕猴与人的视网膜电图比较  

The Comparation of the Electroretinogram(ERG) between Normal Rhesus Monkeys and Humans

作　　者：夏峰[1] 安晶[1] 张磊[1] 刘锐[1] 张作明[1] 

机构地区：[1]第四军医大学航空航天医学系航临教研室,西安710032

出　　处：《中国比较医学杂志》2012年第7期32-35,共4页Chinese Journal of Comparative Medicine

摘　　要：目的比较正常猕猴与人视网膜电图异同,为进一步利用猕猴建立动物模型研究视网膜疾病打下基础。方法健康成年猕猴7只(14只眼)与8例(16只眼)正常人进行视网膜电图检测,对两者Rod-ERG中的b波,Max-ERG的a、b波,Cone-ERG的b波峰时值及波幅和OPs的O2值,Flicker-ERG的P值进行统计学检验。结果猕猴与人的视网膜电图波形结果较为相似,各指标与人的结果相比,潜伏期短,幅值低,但Cone-ERG和Flicker-ERG两者幅值差异不具有统计学意义。结论视网膜电图检测从功能上证明猕猴较其他常用实验动物更接近人,尤其表现在视锥细胞及黄斑区功能,可用作人类视网膜疾病尤其是黄斑区病变的良好动物模型。Objective To compare the difference between the eleetroretinogram （ERG） normal rhesus monkeys and humans, and provide a base for further study on the application of rhesus monkey retinal disease as an experiment model. Methods The electroretnogram （ERG） was recorded in 7 normal rhesus monkey （14 eyes） and 8 human （16 eyes）. The recording items of ERG included rod response b wave, cone response, max response a and b waves, oscillatory potential 02, 30Hz flicker ERG EP. The results were statistically tested. Results The ERG waveform results in rhesus monkey are similar to those in humans, but the amplitudes were decreased and the implicit times were prolonged compared with the humans, and the differences in the amplitude of the Cone ERG and the flicker ERG were not statistically significant. Conclusions The retinal function in rhesus monkey is quite similar to those in humans in the ERG recording. Rhesus monkey is a good animal model for the study on human retinal disease especially the macular.

关 键 词：猕猴 视网膜电图 眼底功能 

分 类 号：R332[医药卫生—人体生理学]