辛唑嘧菌胺的合成与生物活性  

Synthesis of Ametoctradin and Its Bioactivity

作　　者：柴宝山[1,2] 付晓辰[3] 孙旭峰[1] 李青[4] 李志念[1] 

机构地区：[1]沈阳化工研究院有限公司新农药创制与开发国家重点实验室,沈阳110021 [2]郑州大学化学系,郑州450001 [3]吉林大学生命科学院,长春130012 [4]沈阳化工大学,沈阳110142

出　　处：《农药》2012年第9期645-646,674,共3页Agrochemicals

基　　金：国家重点基础研究发展规划项目(973项目:2010CB126105;2010CB735601;2012CB724501);国家"十二五"科技支撑计划项目(2011BAE06B00;2011BAE06B01;2011BAE06B02;2011BAE06B03;2011BAE06B05)

摘　　要：[目的]辛唑嘧菌胺是由巴斯夫公司开发的一类具有新颖化学结构的三唑并嘧啶类杀菌剂。为了研究该类杀菌化合物,探索其合成方法并进行生物活性测定。[方法]以丙酰乙酸甲酯和1H-1,2,4-三唑-5-胺为起始原料,共经过4步反应合成目标化合物辛唑嘧菌胺,经核磁验证其结构。[结果]生物活性测定结果表明该化合物对黄瓜霜霉病具有很好的防治效果。[结论]辛唑嘧菌胺具有优异的杀菌活性,作为一类具有新颖化学结构的杀菌剂,值得进一步研究。[Aims] Ametoctradin is a novel triazolopyrimidine fungicide which was discovered by BASF. To study this class of fungicide, the synthetic method and bio-activity were explored. [Methods] Ametoctradin was synthesized through four steps from methyl 3-oxopentanoate and 1H-1,2,4-triazol-5-amine, and its structure was confirmed by tH NMR. [Results] The test result showed that ametoctradin has good efficiency controlling cucumber downy mildew. [Conclusions] Ametoctradin provides potent fungicidal activity, it deserves further study as a kind of fungicide with novel chemical structure.

关 键 词：辛唑嘧菌胺 合成 杀菌活性 

分 类 号：TQ455.4[化学工程—农药化工]