邻苯二酚亚甲基化合成胡椒环  

Synthesis of 1,3-Benzodioxole by Catechol Methylenation

作　　者：杨涛[1] 赵匡民[1] 张玲[2] 方培华[1] 蒋文伟[1] 

机构地区：[1]四川大学化工学院,成都610064 [2]四川大学化学学院,成都610064

出　　处：《农药》2012年第9期647-650,共4页Agrochemicals

基　　金：四川大学2011年大学生科学探索实验计划(383)

摘　　要：[目的]报道胡椒环合成的新工艺。[方法]以邻苯二酚和二氯甲烷为原料,DMSO作为溶剂,在碱性(K2CO3)环境下合成胡椒环,并通过研究溶剂、温度、反应时间、反应物配比和碱用量对产品收率的影响得到最优工艺条件。[结果]产品收率达89.1%。利用红外光谱、核磁共振和气相色谱分析得产品是胡椒环,纯度达98%。[结论]新工艺是一种适合工业生产的方法。[Aims] A new synthesis techniques of 1,3-benzodioxole was reported. [Methods] 1,3-Benzodioxole was synthesized by using catechol, dichloromethane as the starting materials and DMSO as solvent under the condition of alkali （K2CO3） and normal pressure. In order to get the optimum reaction condition, the effects of material confect, temperature, reaction time, solvent and dosage of alkali were studied. [Results] The yield of product is 89.1%. Results showed that the product is 1,3-benzodioxole by analysis of IR, ~H NMR and GC with the purity of 98%. [Conclusions] New technology is a kind of method suitable for industrial oroduction.

关 键 词：胡椒环 邻苯二酚 合成 二甲亚砜 

分 类 号：TQ453.2[化学工程—农药化工]