绒毛膜羊膜炎对早产儿脑损伤的影响  

Effect of chorioamnionitis on brain injury in preterm infants

作　　者：许丽萍[1] 任榕娜[2] 朱少波[1] 庄红梅[3] 黄仲玲[1] 杨鸿[1] 

机构地区：[1]福建医科大学附属漳州市医院儿科,福建漳州363000 [2]福州总医院儿科,福建福州350025 [3]福建医科大学附属漳州市医院产科,福建漳州363000

出　　处：《中国当代儿科杂志》2012年第9期661-663,共3页Chinese Journal of Contemporary Pediatrics

摘　　要：目的探讨绒毛膜羊膜炎与早产儿脑损伤的相关性。方法选取2008年6月至2011年6月出生的早产儿(28～34周)共88例。根据是否存在绒毛膜羊膜炎,分为病例组(41例)和对照组(47例)。所有的病例生后定期行头颅B超检查,生后3～7 d行颅脑弥散加权成像(DWI)检查,且于纠正胎龄40周时行颅脑MRI检查,比较两组脑室周围白质软化(PVL)和脑室周围-脑室内出血(PVH-IVH)的发生情况。结果病例组PVL的发生率为32%,对照组PVL的发生率为6%,两组比较差异有统计学意义(P<0.05)。而两组PVH-IVH的发生率分别为27%和23%,差异无统计学意义(P>0.05)。结论绒毛膜羊膜炎与早产儿脑损伤有一定的关系,可使早产儿PVL的发生率增加,而对PVH-IVH的影响不大。Objective To explore the association between chorioamnionitis and brain injury in preterm infants.Methods A total of 88 preterm infants（28-34 weeks）,who were born between June 2008 and June 2011,were divided into a case group（n=41） and a control group（n=47） according to whether or not they had chorioamnionitis.All the infants were examined by brain ultrasonography periodically after birth and underwent brain diffusion weighted imaging（DWI） between 3 and 7 days after birth.The two groups were compared in terms of the incidence of periventricular leukomalacia（PVL） and periventricular and intraventricular hemorrhage（PVH-IVH） by brain magnetic resonance imaging（MRI） at the corrected gestational age of 40 weeks.Results There was statistical significance in the incidence of PVL between the case and the control groups（32% vs 6%;P0.05）,but no significant difference in the incidence of PVH-IVH between the two groups（27% vs 23%;P0.05）.Conclusions Chorioamnionitis is associated with brain injury in preterm infants,increasing the incidence of PVL but having little influence over the incidence of PVH-IVH.

关 键 词：绒毛膜羊膜炎 脑损伤 早产儿 

分 类 号：R722.6[医药卫生—儿科]