垂体腺瘤继发库欣病病理分析  

Pathologic Analysis of Secondary Cushing Disease due to Pituitary Adenoma

作　　者：戴芳[1] 王丽[1] 鞠海兵[1] 赵玺龙[1] 杨倩[2] 成友华[3] 王力[1] 宋蜀怜 崔静[1] 蔡琳[1] 

机构地区：[1]成都军区昆明总医院病理科,昆明650032 [2]昆明市第一人民医院病理科,昆明650032 [3]成都军区昆明总医院放射科,昆明650032

出　　处：《解放军医药杂志》2012年第8期23-26,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：云南省自然科学基金资助项目(2002C0024Q)

摘　　要：目的探讨垂体腺瘤的病理特征,分析其与库欣病的关系。方法对1例垂体促肾上腺皮质激素(ACTH)腺瘤继发库欣病的临床资料进行回顾性分析。结果本例手术切除垂体腺瘤后送病理检查,镜下可见肿瘤细胞密集,弥漫排列或呈裂隙状结构,瘤细胞巢之间为血管丰富的纤细间质;免疫组化:垂体腺瘤ACTH阳性,胞浆着色,CD56、CgA、EMA、Syn、Vim胞膜和胞浆阳性,Ki-67核阳性。病理诊断为垂体ACTH腺瘤。结论垂体腺瘤免疫组化检测可作为功能性垂体腺瘤病理诊断的主要手段。垂体腺瘤分泌过多的ACTH是库欣病的病因。Objective To explore the pathologic characteristics of pituitary adenoma and analyze the relationship between pathologic types of pituitary adenoma with cushing disease.Methods A clinical data of pituitary promote adrenal cortical hormone（ACTH） adenoma combined with cushing disease was retrospectively analyzed.Results Dense,diffuse arrangement or slit-shaped tumor cells were found under microscope by pathologic examination after surgical ablation with vascular rich fine interstitial in tumor cell nests;Immunohistochemistry showed pituitary adenoma ACTH was positive,cytoplasm shading,CD56,CgA,EMA,Syn,Vim cell membrane and the cytoplasm positive,and Ki-67 nuclear positive.The pathological diagnosis proved it pituitary adenoma of ACTH.Conclusion Immunohistochemical detection for pituitary adenoma is a main means as functional pituitary adenoma pathology diagnosis.Pituitary adenomas which secreted excessive ACTH is the pathogeny for cushing disease.

关 键 词：垂体肿瘤 垂体ACTH分泌过多 库欣综合征 病理学 临床 

分 类 号：R584[医药卫生—内分泌] R365[医药卫生—内科学]