化学小分子reversine诱导细胞去分化的研究进展  

RESEARCH PROGRESS OF CELL DEDIFFERENTIATION INDUCED BY reversine

作　　者：胡旭琪[1] 张小磊[1] 周一飞[1] 余洋[1] 徐华梓[1] 

机构地区：[1]温州医学院附属第二医院骨科,浙江温州325000

出　　处：《中国修复重建外科杂志》2012年第9期1126-1129,共4页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：温州市科学技术局资助项目(S20100048;Y20100357;Y20100211)~~

摘　　要：目的总结目前将成体细胞转变成干细胞的常用技术,并对化学小分子reversine诱导细胞去分化的研究进展进行综述。方法查阅近年来关于成体细胞转变为干细胞及reversine诱导细胞去分化的相关文献,并进行总结分析。结果通过体细胞核转移技术、基因转染技术等方法将成体细胞转变成干细胞存在某些缺点,而reversine诱导细胞去分化具备独特优势,但其机制尚未完全明确。结论化学小分子reversine诱导细胞去分化有望成为诱导成体细胞转变为干细胞的主要方法。Objective To review the research progress of different ways of stem cells generation and cells dedifferentiation induced by reversine. Methods The papers related to reversine inducing cells dedifferentiation and stem cells generation were reviewed. Results To obtain stem cells, there are always some disadvantages via somatic cell nuclear transfer or gene transfection. However reversine, a small molecule, can induce cells dedifferentiation which has unique advantage. But its mechanism is still unclear. Conclusion The chemical approach for generation of induced pluripotent stem cells by reversine may take the place of other methods.

关 键 词：多能干细胞 reversine 去分化 重新编程 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]