常规MRI及DWI动态观察兔高血压脑病模型  

MRI and DWI dynamic observation on hypertensive encephalopathy in rabbit models

作　　者：高波[1] 吕翠[2] 刘奉立[1] 于国华[3] 巴茂文[4] 

机构地区：[1]烟台毓璜顶医院影像科,山东烟台264000 [2]烟台市烟台山医院神经内科,山东烟台264001 [3]烟台毓璜顶医院病理科,山东烟台264000 [4]烟台毓璜顶医院神经内科,山东烟台264000

出　　处：《中国医学影像技术》2012年第9期1619-1622,共4页Chinese Journal of Medical Imaging Technology

基　　金：烟台市科技发展计划(2008142-4)

摘　　要：目的观察兔高血压脑病(HTE)模型的动态MRI表现及DWI变化。方法选择健康成年新西兰大白兔20只,随机分成A组和B组,每组10只。A组采用双肾单夹型改良法建立慢性高血压模型;B组肌内注射重酒石酸间羟胺建立急性高血压动物模型。在不同时间点行常规MR及DWI扫描,计算所选ROI的ADC值,动态对比观察前、中、后不同部位脑组织信号改变和ADC值变化情况。结果 B组1只在实验中死亡,其余9只均在脑后部出现斑片状稍长T1长T2信号,DWI呈等或稍高信号,注药后ADC值随时间而增高,在第9天达高峰,停药1周后完全恢复正常。A组无异常表现。结论兔HTE的特征性表现为脑后部血管源性脑水肿,DWI可从分子水平观察脑水肿的分布及其动态变化。Objective To investigate the dynamic changes of hypertensive encephalopathy （HTE） of rabbit models with MRI and DWI. Methods Totally 20 adult New Zealand white rabbits were randomly divided into group A and B, contained 10 rabbits. Modified Gloidblatt 2K1C were used in rabbits to establish chronic hypertension model in group A, while intramuscular injection of Metaraminol Bitartrate was performed to build acute hypertension models in group B. Routine brain MRI and DWI were obtained and ADC values were calculated in selected ROI. Variations of signal intensities and ADC values were compared in the anterior, middle and posterior brain regions. Results One rabbit died in group B. Patchy slightly hypo-intensities on T1WI and hyper-intensities on T2WI were observed in posterior brain regions in 9 rabbits of group B, which disappeared completely after drug withdrawal for 1 week, and slight hyper-intensities or iso-intensities were observed on DWI. ADC values increased with the time of injection going, and arrived to peak after 9 days. No positive finding in group A was obtained. Conclusion Vasogenic edema in posterior brain regions is the characteristic presentation of HTE of rabbits. DWI could provide information of distribution and dynamic changes of brain edema.

关 键 词：高血压脑病 模型 动物 扩散磁共振成像 

分 类 号：R544.1[医药卫生—心血管疾病] R445.2[医药卫生—内科学]