Tei指数评价大鼠超急性期心肌梗死左心功能  

Tei index in evaluation on left ventricular dysfunction in early phase acute myocardial infarction in rats

作　　者：林蔚[1] 白旭东[1] 刘美佳[1] 

机构地区：[1]吉林大学第二医院超声科,吉林长春130041

出　　处：《中国医学影像技术》2012年第9期1623-1626,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨Tei指数对评价大鼠超急性期心肌梗死后左心功能的作用。方法将健康雄性Wistar大鼠23只随机分为两组:13只予垂体后叶素腹腔注射(实验组),10只予等量生理盐水腹腔注射(对照组)。建模后分别记录两组大鼠心电图,用超声心动图检测获取左心室射血分数(EF)、等容收缩时间(ICT)、射血时间(ET)及等容舒张时间(IRT),然后取心肌组织行病理检查。结果实验组ICT、Tei指数较对照组显著增加(P<0.01)。Pearson相关分析显示,ICT及Tei指数与心电图ST段抬高程度、EF相关性良好(P<0.01)。结论 Tei指数及其相关参数能客观评价大鼠超急性期心肌梗死的左心功能,可作为基础研究中判断该期心功能异常的良好指标。Objective To observe the value of Tei index in evaluation on left ventricular dysfunction in early stage of acute myocardial infarction （AMI） in rat. Methods A total of 23 healthy male Wistar rats were randomly classified into experimental group （n= 13） and control group （n= 10）, and intraperitoneal injecting of Pituitrin or saline was performed, respectively. Parameters were measured with electrocardiography, and left ventricular ejection fraction （EF）, isovolumetric contraction time （ICT）, ejection time （ET） and isovolumic relaxation time （IRT） were obtained with echocardiography after modeling. Then pathological examination was performed in myocardium tissue sections. Results Compared with control group, ICT and Tei index of experimental group significantly increased （P〈0.01）. Pearson correlation analysis showed ICT and Tel index were well correlated with ST segment elevation and EF （P〈0.01）. Conclusion Tei index and the related parameters are efficient enough to evaluate left ventricular function after rat AMI in super early period, which can be used for basic research in evaluation of cardiac function.

关 键 词：心肌梗死 超急性期 TEI指数 模型 动物 

分 类 号：R540.45[医药卫生—心血管疾病] R-332[医药卫生—内科学]