细菌mRNA的降解机制  

Mechanisms of mRNA Degradation in Bacteria

作　　者：谢兆辉[1] 

机构地区：[1]德州学院生物系,山东省高校生物技术与生物资源利用重点实验室,山东功能大分子生物物理重点实验室,山东德州253023

出　　处：《中国生物化学与分子生物学报》2012年第9期788-792,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.11172062)~~

摘　　要：在细菌中,mRNA降解具有重要的意义,它不仅可以再循环核苷酸,而且还可以根据生长条件的变化调控基因表达.细菌mRNA的降解机制可以分为3种:①mRNA的一般降解途径;②mRNA的质量控制途径;③小RNA介导的降解途径.这些途径有些与真核生物的mRNA降解途径存在很大差异,有些在真核生物中消失了.另外,mRNA降解途径还可以直接调控细菌致病因子的表达,这使得细菌mRNA的降解途径很有希望成为药物研发的新靶标,或疫苗制备的新平台,以应对越来越严重的细菌耐药性问题.本文综述了细菌mRNA的降解机制,并对其应用前景进行了展望.In bacteria,mRNA degradation plays an important role,not only in recycling nucleotides but also in controlling gene expression in response to changing growth conditions.The mechanisms of bacterial mRNA degradation can be classified into 3 models：① the common mRNA degradation pathway;② the mRNA quality control pathway;③ small RNA mediated mRNA degradation pathway.Many processes of these pathways either had great difference with those of eukaryotes,or missed in eukaryotes.Furthermore,these mRNA degradation pathways also directly regulate bacterial virulence factor expression.All these make mRNA degradation pathways possible serve as a novel target for exploiting antimicrobial drug,or new platform for vaccine preparation,to combat the rapid emergence of bacteria drug-resistant.In this paper,the bacterial mRNA degradation pathways will be reviewed,and the application perspective of these mechanisms will also be speculated.

关 键 词：MRNA降解 一般降解途径 mRNA质量控制途径 小RNA介导途径 药物靶点 

分 类 号：Q755[生物学—分子生物学]