Radaway抗辐射胶囊对小鼠辐射损伤的保护作用  

Protective Effects of Radaway Radioprotection Capsule on Radition Injured Mice

作　　者：赵翠霞[1] 袁雪芬[1] 孙莉[1] 王晓丹[1] 谢韬[1] 

机构地区：[1]辽宁省疾病预防控制中心,辽宁省卫生安全重点实验室,辽宁沈阳110005

出　　处：《中国辐射卫生》2012年第3期259-260,共2页Chinese Journal of Radiological Health

摘　　要：目的观察Radaway抗辐射胶囊对小鼠γ射线辐射损伤的保护作用。方法将120只雄性昆明小鼠随机分为I(外周血白细胞计数)、II(骨髓细胞微核检测)、III(骨髓DNA含量测定)3大组,每大组又随机分为高、中、低剂量组和辐射对照组。各组根据不同指标选择不同的照射时间均以同一剂量γ射线全身照射1次。结果以3Gy剂量照射后第14天各剂量组的外周血白细胞计数均显著高于辐射对照组(P<0.01);照射后第3天,中、低剂量组的骨髓细胞微核率显著低于辐射对照组(P<0.01),低剂量组的骨髓DNA含量显著高于辐射对照组(P<0.01)。结论Radaway抗辐射胶囊对小鼠γ射线辐射损伤具有显著的保护作用。Objective To observe the protective effects of Radaway radioprotection capsule on radition injured mice. Methods 120 female Kunming mice were randomly divided into 3 groups by the processing as peripheral white blood cell count（ group I） , marrow cell micronuelci detection（ group II） , and bone marrow DNA count（ group III）. And for each group, mice were further partitioned into low, middle and high dosage groups and radiation control group. The mice were all exposed by 3Gy radiation. Results The peripheral white blood cell level on the 14th day after radiation in three dose groups were all significantly higher than that of radiation control group. On the 3ra day after radiation, comparing with radiation control group micronucleus rate of marrow cells in middle and low dose groups was significantly lower, DNA count in bone marrow in low dose group was significantly higher. Conclutions Radaway radioprotection capsule has significantly protective effects on γ - ray radiation injuries of mice.

关 键 词：Γ射线 辐射损伤 白细胞计数 骨髓细胞微核率 骨髓DNA含量 

分 类 号：R818[医药卫生—放射医学]