Aqueous-mediated Michael Addition of Active Methylene Compounds with Nitroalkenes  

作　　者：董文凯 徐东成 谢建武 

机构地区：[1]Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China

出　　处：《Chinese Journal of Chemistry》2012年第8期1771-1774,共4页中国化学（英文版）

摘　　要：A simple, atom economical and highly efficient green protocol has been developed for the synthesis of Michael adducts of nitroalkenes and 2-amino-2-chromene derivatives by Michael addition of active methylene compounds （such as malononitrile and ethyl cyanoacetate） to nitroalkenes under aqueous-mediated conditions. This green approach provided the desired products in high yields and the reaction scope proved to be quite broad.A simple, atom economical and highly efficient green protocol has been developed for the synthesis of Michael adducts of nitroalkenes and 2-amino-2-chromene derivatives by Michael addition of active methylene compounds （such as malononitrile and ethyl cyanoacetate） to nitroalkenes under aqueous-mediated conditions. This green approach provided the desired products in high yields and the reaction scope proved to be quite broad.

关 键 词：Michael addition green chemistry CHROMENES NITROALKENES domino reaction 

分 类 号：O623[理学—有机化学] O621.256.7[理学—化学]