怡肾丸Ⅰ号对UUO大鼠行为性状及肾组织形态学的影响  

Effects of Yishenwan Ⅰon Behavior and Renal Morphology in UUO Rats

作　　者：周珂[1] 何泽云[1] 龙华君[2] 左和宁[1] 彭亚军[1] 

机构地区：[1]湖南中医药大学第一附属医院肾内科,长沙410007 [2]湖南省中医药研究院附属医院,长沙410006

出　　处：《中国中医药现代远程教育》2012年第15期161-163,共3页Chinese Medicine Modern Distance Education of China

基　　金：湖南省科技厅资助项目[No:(2009)42];湖南省自然科学基金(重点)[No:09JJ3064];湖南省高校创新平台[No:09K059]

摘　　要：目的观察怡肾丸Ⅰ号对单侧输尿管结扎大鼠生活状态、体重及其肾脏病理的影响。方法将50只SD大鼠分为怡肾丸Ⅰ号组、依那普利组、空白组、假手术组及模型组,连续灌胃14d后,观察各组大鼠的生活状态、体重及其肾组织的病理改变情况。结果怡肾丸Ⅰ号组和依那普利组生活状态、体重和肾组织的病理改变方面都明显轻于模型组(P<0.01)。结论怡肾丸Ⅰ号对UUO大鼠的生活状态、体重和肾组织都有明显改善。Objective To evaluate the effect of Yishenwan Ⅰ on life station, body weight and renal pathological on unilateral ureteral ligation rats. Methods 50 SD rats were divided YishenwanⅠgroup, enalapril group, control group, sham operation group and model group, respectively. After continuously being intragastriced 14 days, the life sttation, body weight and kidney tissue pathological of rats in each group were observated. Results After 14 days, the life station, weight and pathology of Yishenwan I group and enalapril group were significantly different from the other groups rats （P 〈 0.01）. Conclusion It is a significant improvement of Yi shenwan Ⅰ on the life station, body weight and renal pathological UUO rats.

关 键 词：怡肾丸Ⅰ号 UUO 大鼠 生活状态 肾组织形态学 

分 类 号：R285.5[医药卫生—中药学]