妊娠期高血压疾病中血清可溶性Endoglin水平变化的研究  

Study on changes of Endoglin inmaternal serum in hypertensive disorder complicating pregnancy

作　　者：杜伟[1] 王晶[1] 王心[1] 尚丽新[1] 

机构地区：[1]安徽医科大学北京军区总医院临床医学系,安徽合肥230032

出　　处：《中国优生与遗传杂志》2012年第9期54-55,87,共3页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金(81050001)

摘　　要：目的检测正常妊娠和妊娠期高血压疾病患者血清中Endoglin的水平,探究其与妊娠期高血压疾病的发病关系及意义。方法采用酶联免疫吸附双抗体夹心法(ELISA)检测44例妊娠期高血压疾病患者(妊娠期高血压疾病组,其中妊娠期高血压15例、轻度子痫前期14例、重度子痫前期15例)及16例正常晚期妊娠妇女(对照组),22例正常中期妊娠妇女血清中Endoglin水平。结果妊娠期高血压疾病组血清Endoglin浓度为(2.86±2.15)ng/ml,正常晚期妊娠组为(1.14+0.46)ng/ml,两组比较差异有统计学意义(P<0.05)。妊娠期高血压、轻度子痫前期、重度子痫前期患者血清中可溶性Endoglin水平逐渐升高[分别为(1.68±0.78)ng/ml,(2.49±1.10)ng/ml,(4.44±2.94)ng/ml],各组间差异有统计学意义(P<0.05),且有随孕周增加而逐渐增加的趋势。正常中期妊娠组血清中Endoglin浓度为(0.83±0.32)ng/ml,与正常晚期妊娠组比较差异有统计学意义。结论血清Endoglin水平升高可能与妊娠期高血压疾病的发病及病情发展有关,并有可能成为疾病的预测指标。Objective： To detect serum levels of Endoglin in the patients of normal pregnancy and hypertensive disorder complicating pregnancy as well as to explore the relationship and pathogenesis with hypertensive disorder complicating pregnancy.. Methods ： Serum samples were collected from 44women suffered from hypertensive disorder complicating pregnancy （ hypertensive disorder complicating pregnancy group） and 16 normal pregnant women （control group）, 22 second trimester normal pregnant women, endoglin levels were determined with enzyme - linked immunosorbent assay （ELISA）. Results： Serum levels of endoglin （2. 86 ± 2. 15 ） ng/ml in hypertensive disorder complicating pregnancy group were significantly higher than that （ 1.14 ± 0. 46） ng/ml in control group （ P 〈 0. 05 ）. Serum levels of endoglin in gestation hypertension （1.68 ± 0. 78 ） ng/ml, mild preeelampsia （2. 49 ± 1.10） ng/ml, and severe preeclampsia （4. 44 2. 94） ng/ml group were gradually elevated, there were significant differences among them （P 〈 0. 05 ）. Serum levels of Endoglin increased from the second trimester （ 1.14 ±0. 46） ng/ml to the third trimester （0. 83 ±0. 32） ng/ml, there are significant difference between them. Conclusion： Endoglin might play an important role in the pathogenesis and development of hypertensive disorder complicating pregnancy, which may be the new indicators for predicting hypertensive disorder complicating pregnancy.

关 键 词：妊娠 高血压 可溶性ENDOGLIN 子痫前期 

分 类 号：R714.25[医药卫生—妇产科学]