正常妊娠及妊娠期糖尿病患者血脂代谢特点  

Serum-lipid metabolic characteristics of normal pregnancy and gestational diabetes mellitus patients

作　　者：王敏[1] 吴晓华[1] 辛静[1] 李真[1] 

机构地区：[1]第三军医大学附属新桥医院妇产科,重庆400037

出　　处：《中国优生与遗传杂志》2012年第9期66-68,共3页Chinese Journal of Birth Health & Heredity

基　　金：国家自然基金资助项目(基金编号30973203)

摘　　要：目的观察妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇和正常妊娠孕妇不同孕期的血脂代谢特点,探讨妊娠早中期血脂变化与GDM的关系。方法选择在我院门诊就诊的正常健康孕妇(A组)及GDM孕妇(B组),两组分别于孕14-19周、28-34周抽取空腹静脉血测定血浆总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白AI(APOAI)、载脂蛋白B(APOB)、脂蛋白A(LPA)。结果 (1)正常妊娠组与GDM组孕妇随着孕周的增加,TC、TG、APOB、LDL值显著升高(P<0.01),APOAI值明显升高(P<0.05),正常妊娠组中LPA值随孕周增加明显升高(P<0.05);(2)GDM组孕妇在孕14-19周及孕28-34周,TG值较同孕周的正常妊娠组显著升高(P<0.01),APOB值在GDM组孕14-19周时明显高于同期正常妊娠组(P<0.01);(3)TC、LDL、HDL、APOAI、LPA在两组不同孕周间比较均无显著性差异(P>0.05),HDL值随两组孕周增加升高不明显(P>0.05)。结论GDM孕妇在不同孕周的甘油三酯水平均高于正常妊娠孕妇;GDM孕妇在孕早中期较正常妊娠孕妇存在更早期、更明显的脂代谢紊乱。在孕早中期监测血糖、血脂水平,及时制定合理的饮食计划,可减少GDM的发生和尽早防治其可能带来的母婴危害。Objective： To observe Serum- lipid metabolic characteristics of pregnant women with gestational diabetes mellitus （GDM） and normal pregnant women in different pregnancy and to explore the relationship of early and mid - pregnancy Serum - lipid changes with GDM. Methods： Selected normal healthy pregnant women （A group） and pregnant women with GDM （B group） in our hospital outpatient, the two groups were extracted of gestation fasting venous blood in the 14 - 19 weeks and 28 - 34 weeks pregnant respectively in determination of plasma total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL）, low density lipoprotein （LDL）, apolipoprotein AI （APOAI）, apolipoprotein B （of APOB） , lipoprotein A （LPA）. Results： （1） With the increase of gestational weeks of normal pregnancy group and GDM group, the levels of TC, TG, APOB, LDL were significantly increased （ P 〈 0. 01 ） , the level of APOAI was obviously higher （ P 〈 0.05 ） , the level of LPA was obviously higher with the increase of gestational weeks in normal pregnancy group （P 〈0. 05）. （2） In the 14 - 19 and 28 -34 pregnancy weeks of GDM group, the level of TG was significantly increased compared with the normal pregnancy group at the same gestational age （ P 〈 0. 01 ）, the level of APOB in the GDM group obviously higher than the same period of normal pregnancy group in the 14 - 19 pregnancy weeks （P 〈0. 01 ）. （3） The two groups showed no significant difference of TC, LDL, HDL, APOAI, LPA in different gestational weeks （ P 〉 0. 05 ） , the HDL level of two groups was not obviously higher with the increase of pregnancy weeks （ P 〉 0.05 ）. Conclusion ： The TG level of pregnant women with GDM is higher than normal pregnant women in different gestational weeks. Compared to normal pregnant women, pregnant women with GDM have more earlier, more obvious disorders of Serum - lipid metabolism in early and mid - pregnancy. During this period, monitoring of the leve

关 键 词：妊娠 妊娠期糖尿病 血脂 脂代谢 

分 类 号：R714.25[医药卫生—妇产科学]