变态反应性支气管肺曲菌病48例临床分析  

Clinical analysis of allergic bronchopulmonary aspergiliosis ： a report of 48 patients

作　　者：苏奕亮[1] 高蓓兰[1] 刘锦铭[1] 曹卫军[1] 程克斌[1] 

机构地区：[1]同济大学附属上海市肺科医院呼吸内科,200433

出　　处：《中华全科医师杂志》2012年第9期685-686,共2页Chinese Journal of General Practitioners

基　　金：上海市肺科医院科研课题（fKl021）

摘　　要：回顾2004年至2011年确诊的48例变态反应性支气管肺曲菌病患者的临床资料。其中男23例，女25例，年龄（36±15）岁；95．8％（46／48）有发作性喘息、89．6％（43／48）咳嗽，85．4％（41／48）咳痰。患者嗜酸性粒细胞和总IgE均有增高，曲霉菌抗原皮内试验呈速发阳性反应，烟曲霉特异性IgE均增高，26例痰曲霉培养阳性；胸部CT表现45例见斑片渗出影，40例病灶呈游走性，35例见中心性支气管扩张，18例见痰栓征象；肺功能主要表现为阻塞性通气功能障碍。To retrospectively analyze the clinical data of 48 patients with allergic bronchopulmonary aspergillosis （ABPA） at Shanghai Puhnonary Hospital. There were 23 males and 25 females with a mean age of （36 ± 15） years. Their clinical manifestations included wheeze, cough, sputum production, sputum plugs, fever, hemoptysis, weight loss, chest pain, weakness and night sweats. They had a high peripheral blood eosinophilia, a higher serum total IgE, a higher level of aspergillosis fumigatus-specific IgE and positive immediate skin-prick test to aspergillus fumigatus. Aspergillus species were detected in sputum samples of 26 patients. Chest computed tomography （CT） was performed in 48 patients. There were patchy infiltrations （ n = 45 ）, transient infiltrations （ n = 40 ）, central bronchiectasis （ n = 35 ） and mucoid impaction （n = 18）. Obstructive ventilation dysfunction was confirmed by lung function test.

关 键 词：超敏反应 曲霉菌病 变态反应性支气管肺 

分 类 号：R519[医药卫生—内科学]