吸入不同浓度薰衣草精油对大学生血压的影响  

Effect of different concentrations inhalation of lavender essential oil on blood pressure of collage students

作　　者：李家霞[1] 刘云峰[1] 傅佳[2] 李光武[3] 

机构地区：[1]巢湖市第二人民医院,巢湖238000 [2]安徽医科大学第一附属医院,合肥230000 [3]安徽医科大学神经生物学研究所,合肥230032

出　　处：《中华中医药杂志》2012年第9期2397-2401,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金(No.81000589);安徽省自然科学基金(No.090413145)~~

摘　　要：目的:探讨吸入不同浓度薰衣草精油对健康大学生血压的影响及其可能作用机制。方法:采用气相色谱-质谱(GC-MS)分析薰衣草精油化学成分;选择健康大学生,嗅觉检查采用改良康涅狄格州化学感觉临床研究中心(CCCRC)的方法检测嗅觉正常162名,随机分为4组,分别吸入薰衣草精油浓度为100%、1%、1‰和蒸馏水后均采用24h动态血压仪观测血压和心率变化;测定血浆肾素活性(PRA)、血管紧张素Ⅰ(AngⅠ)、血管紧张素Ⅱ(AngⅡ)和醛固酮(ALD)等指标。结果:①GC-MS分析共确认薰衣草精油29种化学组分,其主要化学成分为芳樟醇(25.49%)和乙酸芳樟酯(25.54%);②100%薰衣草精油组吸入后15min平均动脉压(MAP)下降(P<0.05),作用持续60min;1%薰衣草精油组吸入后15min MAP下降(P<0.05),作用持续120min;1‰薰衣草精油组吸入30min后MAP下降(P<0.05),作用持续60min。4组实验前后心率差异均无统计学意义;③1%薰衣草精油组吸入1%薰衣草精油后血浆PRA、AngⅠ、AngⅡ和ALD均降低(P<0.05);而蒸馏水组吸入蒸馏水后血浆PRA、AngⅠ、AngⅡ和ALD均无明显变化。结论:吸入3种不同浓度薰衣草精油均能降低健康人MAP,其中1%薰衣草精油组血压降低较明显,作用时间久,且对心率均没有影响,其可能作用机制是通过降低血浆PRA、AngⅠ、AngⅡ和ALD的浓度而降低血压。Objective： To investigate the effect of different concentrations inhalation of lavender essential oil to collage students blood pressure and its possible mechanism. Methods： Gas chromatography - mass spectrometry （GC-MS） analysis was used for detecting chemical composition of lavender essential oil. Selected 162 cases of to detect the normal sense of smell by using the improved olfactory sensation Connecticut Clinical Research Center of Chemistry （CCCRC）, they were randomly divided into 4 groups, respectively, the concentration of inhalation of lavender essential oil were 100%, 1%, 1%0, and distilled water, after the inhalation, blood pressure and heart rate were observed by 24h ambulatory blood pressure instrumentations. And the plasma renin activity （PRA）, angiotensin I （AngI）, angiotensin II （AnglI）, aldosterone （ALD） and other indicators were measured. Results： ①GC-MS analysis confirmed a total of 29 kinds of chemical components of lavender essential oil, its main chemical composition were linalool （25.49%） and linalyl acetate （25.54%）; ②The mean arterial pressure （MAP） decreased in 100% lavender essential oil group after inhaling 15min （P〈0.05）, which lasted for 60rain; MAP decreased in l% lavender essential oil group after inhaling 15min （P〈0.05）, which lasted for 120min; MAP decreased in 1‰ lavender essential oil group after inhalation 30min （P〈0.05） which lasted for 60min. In distilled water, the blood pressure did not change significantly. There were no significant changes among four groups in heart rate before and after experiment. ③Plasma PRA, AngI, AnglI and ALD were lowcr in l% inhalation of lavender essential oil group, the difference was statistically significant （P〈0.05）; Meanwhile the plasma PRA, AngI, Angll, and ALD had no significant changes in distilled water group. Conclusion： 3 different concentrations of inhalation of lavender essential oil can reduce the MAP of collage students, of which 1% lavender essential oil c

关 键 词：薰衣草精油 血压 气相色谱-质谱分析 肾素 血管紧张素Ⅰ、Ⅱ 醛固酮 

分 类 号：R285.5[医药卫生—中药学]