一个简单、环境友好的硅胶固载硫酸催化Biginelli反应体系(英文)  

A Simple and Environmentally Benign Protocol for Biginelli Reactions Catalyzed by Silica-Bonded S-Sulfonic Acid

作　　者：Mahmood TAJBAKHSH Yousef RANJBAR Abdolhosein MASUODI Samad KHAKSAR 

机构地区：[1]Chemistry Department,University of Mazandaran [2]Chemistry Department,Payame Noor University [3]Chemistry Department,Islamic Azad University

出　　处：《催化学报》2012年第9期1542-1545,共4页

基　　金：supported by the Research Council of Payame Noor University

摘　　要：A protocol for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and-thiones was developed by means of a three-component condensation of an aldehyde,a β-dicarbonyl compound,and urea or thiourea in acetic acid catalyzed by silica-bonded S-sulfonic acid.Compared to the classical Biginelli reaction conditions,this new protocol has the advantages of consistently excellent yields and short reaction times.After the reaction,the catalyst could be recovered easily and reused with little change in its activity.A protocol for the synthesis of 3,4-dihydropyrimidin-2（1H）-ones and-thiones was developed by means of a three-component condensation of an aldehyde,a β-dicarbonyl compound,and urea or thiourea in acetic acid catalyzed by silica-bonded S-sulfonic acid.Compared to the classical Biginelli reaction conditions,this new protocol has the advantages of consistently excellent yields and short reaction times.After the reaction,the catalyst could be recovered easily and reused with little change in its activity.

关 键 词：BIGINELLI REACTION silica-bonded S-sulfonic ACID DIHYDROPYRIMIDINONE 

分 类 号：O643.32[理学—物理化学]