先兆子痫患者血浆和胎盘降钙素基因相关肽含量的测定  

Plasma and placental calcitonin gene-related peptide in pregnancies complicated by severe preeolampaia

作　　者：宋立艳 张东宏[1] 李佳[2] 吴雅冬[2] 赵莲如 

机构地区：[1]黑龙江省佳木斯市中心医院妇产科,154002 [2]佳木斯医学院

出　　处：《中国优生与遗传杂志》2000年第2期63-64,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的 :为研究降钙素基因相关肽在先兆子痫病生机制中的作用。方法 :本文采用放射免疫测定法测定了 2 1例健康未妊娠妇女 (未妊娠组 ) ,2 5例正常妊娠妇女 (妊娠组 )及 2 5例先兆子痫患者 (先兆子痫组 )血浆降钙素基因相关肽水平 ,同时测定了妊娠组与先兆子痫组胎盘组织及胎儿血浆降钙素基因相关肽水平。结果 :在妊娠组与先兆子痫组间 ,母体与胎儿血浆中以及胎盘组织中降钙素基因相关肽含量均无明显变化 (P >0 .0 5 ) ,但母体与胎儿血浆含量具有明显相关性。结论Objective:To study the pathophysiology action of calcitonin generelated peptide(CGRP) on severe preeclampsia.Method:Plasma CGRP levels were measured by radioimmunoassay in 21 healthy nonpregnant women,25 normal pregnancies and 25 cases with severe preeclampsia,and placental CGRP levels in fetal plasma and placental tissue were measured by the same method in normal pregnancies and severe preeclamsia.Results:The results showed that there was no significant difference of CGRP level in maternal plasma,fetal palsma and placental tissue between normal pregnancies groups and severe pregnancia groups (P>0.05).However,a significant correlation was found between maternal and fetal CGRP level.Conolusions:The findings suggested that CGRP does not seem to play an important role in the pathphysiologic mechanisms of preeclampsia.

关 键 词：降钙素基因相关肽 先兆子痫 血浆 含量 测定 

分 类 号：R714.24[医药卫生—妇产科学]