丹参酮ⅡA对动脉粥样硬化症患者血管内皮细胞功能的干预作用  

Intervention Effect of Tanshinone ⅡA on Vascular Endothelial Cell Function in Patients with Atherosclerosis

作　　者：李朝梁 石秋玲[2] 朱平先[3] 

机构地区：[1]深圳市南澳人民医院急诊科,广东深圳518121 [2]深圳市人民医院超声科,广东深圳518000 [3]深圳市龙岗区人民医院内科,广东深圳518172

出　　处：《南昌大学学报（医学版）》2012年第7期44-45,48,共3页Journal of Nanchang University：Medical Sciences

摘　　要：目的研究丹参酮ⅡA注射液对血管内皮细胞(VEC)分泌功能的保护作用。方法选择动脉粥样硬化患者200例,进行干预治疗(予丹参酮ⅡA 10mL静脉点滴,1次·d-1,治疗1周)。在干预前后分别采空腹静脉血检测内皮素(ET)、前列环素(PGI2)、血栓素A2(TXA2),并进行自身前后对照。结果经丹参酮ⅡA干预后动脉粥样硬化患者血液中的ET、TXA2较干预前水平明显降低(P<0.01),而PGI2较干预前明显升高(P<0.01)。结论丹参酮ⅡA注射液能够调整、改善VEC分泌功能的异常状态,VEC可能是丹参酮ⅡA作用的靶点之一。Objective To study the protection effect of tanshinone ⅡA injection on vascular en- dothelial cell function. Methods A total of 200 patients with artery atherosclerosis were treated with intravenous drip of 10 mL tanshinone ⅡA once per day for 1 week. Fasting blood samples were collected for the detection of endothelin （ET）, prostacyclin （PGI2） and thromboxane A2 （TXA2） before and after treatment. Results Compared with levels before treatment, ET and TXA2 levels significantly decreased but PGI2 levels obviously increased after tanshinone ⅡA treat- ment （P〈0.01）. Conclusion Tanshinone ⅡA injection can regulate and improve the abnormali- ties of secretory function of vascular endothelial cells. Vascular endothelial cells may serve as the targets for tanshinone ⅡA action.

关 键 词：丹参酮ⅡA动脉粥样硬化 血管内皮细胞 分泌功能 

分 类 号：R543.12[医药卫生—心血管疾病]