孤立性心肌致密化不全患者左室收缩功能的相关因素分析  

Analysis of Correlative Factors of Left Ventricular Systolic Dysfunction in Patients With Isolated Left Ventricular Noncompaction

作　　者：高晓津[1] 江勇[2] 康连鸣[1] 张健[1] 罗晓亮[1] 蒋文[1] 吕蓉[1] 祝捷[1] 杨跃进[1] 

机构地区：[1]中国医学科学院,北京协和医学院,国家心血管病中心,阜外心血管病医院心内科,100037 [2]中国医学科学院,北京协和医学院,国家心血管病中心,阜外心血管病医院超声科,100037

出　　处：《中国分子心脏病学杂志》2012年第4期197-200,共4页Molecular Cardiology of China

基　　金：北京市科委重大项目(D0906004040291)

摘　　要：目的总结孤立性左室心肌致密化不全(ILVNC)患者的临床资料,并对其左室收缩功能的相关影响因素进行分析。方法连续入选自2006年1月至2010年9月经超声心动图确诊为ILVNC的患者共41例,总结其临床资料,并对可能影响该组患者左室射血分数(LVEF)的因素进行分析。结果 41例患者(男性35例)LVEF均值为31.41±11.21%;最常受累的心肌节段是心尖部(100%受累),其次是心尖段外侧壁(92.7%受累)、心尖段下壁(82.9%受累)和心尖段前壁(70.7%受累)。相关性分析表明,LogNT-proBNP、左室舒张末内径(LVEDD)和室壁运动评分指数(WMSI)与LVEF均呈负相关,r分别为-0.441(P=0.007)、-0.357(P=0.022)以及-0.714(P=0.000),具有显著的统计学意义;受累节段数目和NC/C比值则与LVEF无显著相关性;WMSI与受累节段数目呈正相关(r=0.362,P=0.020),与NC/C比值无显著相关性(P=0.254)。结论 ILVNC患者LVEF左室整体收缩功能与NT-proBNP及LVEDD呈负相关,而与受累心肌节段数目、NC/C比值无明显关联。Objective The purpose of this study was to analyze the correlative factors of left ventricular systolic dysfunction in patients with isolated left ventricular noncompaction （ILVNC）. Methods We summarized the clinical information of 41 patients with ILVNC evaluated by echocar- diography from January 2006 to September 2010. Correlative analysis was used to find the predictors of the left ventricular ejection fraction （LVEF）. Results A total of 41 subjects were enrolled with the mean LVEF of 31.414-11.21%. The most common affected segments are apex （100% affected）, apical lateral （92.7% affected）, apical inferior （82.9% affected）and apical anterior （70.7% affected） segment. LogNT-proBNP, LVEDD and WMSI （Wall Motion Score Index） are negatively correlated with LVEF （r=-0.441, r=-0.357, P〈0.05 respectively）. The number of affected segments and NC/C（non- compaction/compaction）ratio shows no correlation with LVEF. Conclusion Left ventricular systolic function in patients with ILVNC is negatively correlated with LogNT-proBNP and LVEDD. The number of affected segments and NC/C ratio shows no correlation with LVEF in these patients.

关 键 词：心肌病 孤立性左室心肌致密化不全 心力衰竭 左室射血分数 室壁运动 

分 类 号：R541.1[医药卫生—心血管疾病]