血清尿酸水平与代谢综合征相关  

Serum Uric Acid Level is Associated with Metabolic Syndrome

作　　者：张长青[1] 叶巍[1] 邢晓博 马振亮[1] 刘福颂 李晓[1] 姜琳[1] 张筠[1] 赵琛[2] 孙凯[3] 

机构地区：[1]青岛市青岛市第三人民医院,266041 [2]青岛大学医学院解剖教研室,266021 [3]中国医学科学院,北京协和医学院,国家心血管病中心,阜外心血管病医院,100037

出　　处：《中国分子心脏病学杂志》2012年第4期230-232,共3页Molecular Cardiology of China

基　　金：国家重大基础项目2010CB732601

摘　　要：目的探讨血清尿酸水平与中国人群代谢综合征的关系。方法入选960例无心血管病症状的普通社区人群,男751人,女209人,平均年龄41.27岁,所有研究对象进行了详细的问卷调查和体检。计算分性别的血清尿酸四分位数,将研究对象分成4组,观察各组代谢综合征发生情况。结果男性中,代谢综合征患者的血清尿酸水平359.5±66.lumol/L,显著高于非代谢综合征患者319.4±66.7umol/L。女性中,代谢综合征患者的血清尿酸水平304.6±60.7umol/L,显著高于非代谢综合征患者242.9.4±52.9umol/L。血清尿酸四分位分组间代谢综合征的发生率分别为5.8%,8.2%,16.7%和24.1%。在校正了年龄、性别、吸烟状况,饮酒状况,糖尿病家族史、血压、血脂、腰围等混杂因素后,血清尿酸高的对象发生代谢综合征的危险是血清尿酸低的2.24(1.05-4.76)倍,P=0.036。结论血清尿酸水平与代谢综合征显著相关。Objective To investigate the relationship between Serum uric acid level and metabolic syndrome. Methods Total of 960 individu- als, free of cardiovascular disease ,with the average age 41.27 years old （721 men and 209 women）were enrolled, All participants were personally interviewed with a structured questionnaire and physical examination. We classified all participants on sex-specific quartiles of serum uric acid levels. The incidence of metabolic syndrome was investigated. Results The mean concentration of serum uric acid was significantly higher in patients with metabolic syndrome than in participants without metabolic syndrome. The prevalence of the metabolic syndrome was 5.8%, 8.2%, 16.7%, 24.1% among participants in 4 groups respectively. After adjusting for age, gender, smoking status alcohol intake family history of diabetes, blood pressure, total cholesterol and blood glucose, the odds ratios （95% C1） of sex-specific quartiles of serum uric acid for metabolic syndrome were 2.24（1.05-4.76）, P=0.036. Conclusions Serum uric acid level is significantly associated with metabolic syndrome.

关 键 词：血清尿酸 代谢综合征 

分 类 号：R589[医药卫生—内分泌]