奈替米星肾毒性作用的研究  

Nephrotoxicity of netilmicin in children

作　　者：伏洁[1] 邵蔚 于亚平[1] 过国英[1] 傅元凤[1] 李世军[1] 许瑞吉[3] 张中书[3] 王国洪[3] 

机构地区：[1]南京军区南京总医院儿科,江苏南京210002 [2]南京市钟山医院 [3]南京军区南京总医院核医学科

出　　处：《医学研究生学报》2000年第2期87-88,共2页Journal of Medical Postgraduates

摘　　要：目的 :研究奈替米星对儿童的肾毒性。　方法 :应用放射免疫分析法对 2 0例健康儿童和 2 6例因感染性疾病接受奈替米星治疗儿童的尿 β2 微球蛋白 (β2 - MG)、Tam m- Horsfall蛋白 (THP)和白蛋白 (Alb)含量测定。　结果 :奈替米星治疗前尿β2 - MG (1.18± 0 .6 0 ) m g/(g· Cr) ,THP(76 .93± 6 7.19) mg/(g· Cr)和 Alb(6 4.30± 36 .2 2 )μg/(g· Cr) ,明显高于正常对照组 ,分别为 (0 .45± 0 .35 ) mg/(g· Cr)、(11.95± 5 .30 m g) /(g· Cr)、(11.84±5 .40 )μg/(g· Cr) (P<0 .0 1)。奈替米星治疗后尿β2 - MG和 Alb轻度升高 (P >0 .0 5 ) ,而尿 THP轻度降低 (P<0 .0 5 )。　结论 :儿童短期应用奈替米星不会引起严重的肾毒性。Objectives: To investigate netilmicin nephrotoxicity in children. Methods: The urinary concentration of β 2 microglobulin(β 2 MG),Tamm Horfall protein(THP) and albumin(Alb) in 20 normal control and in children receiving netilmicin treatment for infectious diseases were measured by radioimmunoassay . Results: Pretherapy urinary concentrations of β 2 MG (1.18±0.60)mg/(g·Cr),THP ( 76.93 ±67.19)mg/(g·Cr) and Alb (64.30±36.22)μg/(g·Cr) was high as compared with normal control (0.45±0.39)mg/(g·Cr),(11.95±5.30)mg/(g·Cr) and (11.84±5.40)μg/(g·Cr),respectively(P<0.01). After receiving netilmicin treatment,urinary β 2 MG and Alb had mild increasement ( P> 0.05) and urinary THP decreased minimally (P<0.05). Conclusions: Short term treatment with netilmicin does not bring about severe nephrotoxicity in children.

关 键 词：奈替米星 肾毒性 儿童 ALB Β2微球蛋白 TH蛋白 

分 类 号：R978.12[医药卫生—药品]