老年2型糖尿病患者脂代谢的测定及临床意义  

Determination of serum lipids、apolipoprotein and lipoprotein(a)in elderly with non insulin dependent diabetes mellitus

作　　者：周晓钢[1] 叶继诚[1] 周景春[2] 王冬梅[2] 高风荣[2] 

机构地区：[1]内蒙古医学院生物化学教研室,呼和浩特市010059 [2]内蒙古自治区医院,呼和浩特市010059

出　　处：《实用老年医学》2000年第2期76-77,共2页Practical Geriatrics

摘　　要：目的　 探讨老年 2型糖尿病与血脂、载脂蛋白、脂蛋白 (a)之间的关系及其临床测定的意义。　 方法　对 97例老年 2型糖尿病患者及 6 5例老年对照组进行了血清总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)、载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB)及脂蛋白 (a) [Lp(a) ]的测定。　 结果 　老年 2型糖尿病患者血清TC、TG、LDL C、ApoB及Lp(a)水平均显著高于老年对照组。而血清HDL C和ApoAl水平老年 2型糖尿病组显著低于老年对照组　 结论　老年 2型糖尿病患者由于体内胰岛素相对不足及胰岛素抵抗 ,使血脂、载脂蛋白、脂蛋白浓度和组成成分发生变化及功能发生异常 ,从而促进动脉粥样硬化 ,并伴随着血管并发症的发生。因此 ,在对老年糖尿病并发症的预防和控制上 ,应在控制血糖的基础上减少脂肪的摄入 ,以降低高脂血症的发生 。Objective To discuss the relationship between the levels of serum lipids、apolipoprotein(Apo)、lipoprotein(a)[Lp(a)]and elderly with non insulin dependent diabetes mellitus(NIDDM). Methods The levels of serum lipids、Apo and Lp(a)in 97 elderly cases with NIDDM and 65 cases control group were determined. Results The levels of triglyceride(TG)、total cholesterol(TC)、low density lipoprotein cholesterol(LDL C)、ApoB and Lp(a) in NIDDM were higher than those of the control group;While the high density lipoprotein cholesterol (HDL C)and ApoAI were significantly lower than those of the control group. Conclusions Abnormal serum lipid levels maybe the risk factors of angiopathy in elderly with NIDDM.Chronic high glucose and high serum lipids levels play an important role in developing diabetic chronic complications of elderly with NIDDM.

关 键 词：糖尿病 非胰岛素依赖型 血脂 载脂蛋白 

分 类 号：R587.1[医药卫生—内分泌]