What comes first： translational repression or mRNA degradation？ The deepening mystery of microRNA function  

作　　者：Wenqian Hu, Jeff Coller 

机构地区：[1]Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA [2]Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44106, USA

出　　处：《Cell Research》2012年第9期1322-1324,共3页细胞研究（英文版）

摘　　要：While many mechanisms have been proposed for microRNAs （miR- NAs） function, most ultimately cause message degradation. A view has emerged that miRNAs silence gene expression by promoting the association of mRNA decay factors. Recent research results, however, suggest that in both zebrafish and fruit fly, translational inhibition is the initiating event of miRNA-mediated gene silencing.

关 键 词：MRNA降解 MICRORNA 翻译 小分子RNA miRNA RNA介导 基因表达 基因沉默 

分 类 号：Q959.226.4[生物学—动物学] Q522