Histone H2B lysine 120 monoubiquitination is required for embryonic stem cell differentiation  

作　　者：SuChen  JuanLi  Da-LiangWang Fang-LinSun 

机构地区：[1]School of Life Sciences and Technology, Tongji University, Shanghai 200092, China [2]The Advanced Institute of Translational Medicine, Tongji University, Shanghai 200092, China [3]Institute of Epigenetics and Cancer Research, School of Medicine, Tsinghua University, Beijing 100084, China

出　　处：《Cell Research》2012年第9期1402-1405,共4页细胞研究(英文版)

摘　　要：Dear Editor, Histone H2B lysine 120 monoubiquitination (H2B- K120ub) is a key histone modification that plays critical roles in gene transcriptional regulation and higher order chromatin organization in many species [1]. H2BK120ub has been reported to be associated with highly expressed active genes in human cells [2]. In yeast, H2B lysine 123 monoubiquitination (the homolog of mammalian H2B- K120ub) is a determinant of two important histone H3 methylations,

关 键 词：组蛋白修饰 细胞分化 赖氨酸 基因转录调控 胚胎 组蛋白H3 哺乳动物 染色质 

分 类 号：Q789[生物学—分子生物学] Q813